3eqy

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[[Image:3eqy.png|left|200px]]
 
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{{STRUCTURE_3eqy| PDB=3eqy | SCENE= }}
{{STRUCTURE_3eqy| PDB=3eqy | SCENE= }}
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===Crystal structure of human MDMX in complex with a 12-mer peptide inhibitor===
===Crystal structure of human MDMX in complex with a 12-mer peptide inhibitor===
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{{ABSTRACT_PUBMED_19255450}}
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{{ABSTRACT_PUBMED_19255450}}
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==Function==
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[[http://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN]] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref>
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:019255450</ref><references group="xtra"/>
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<ref group="xtra">PMID:019255450</ref><references group="xtra"/><references/>
[[Category: Lu, W.]]
[[Category: Lu, W.]]
[[Category: Pazgier, M.]]
[[Category: Pazgier, M.]]

Revision as of 07:42, 2 April 2014

Template:STRUCTURE 3eqy

Contents

Crystal structure of human MDMX in complex with a 12-mer peptide inhibitor

Template:ABSTRACT PUBMED 19255450

Function

[MDM4_HUMAN] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.[1] [2]

About this Structure

3eqy is a 4 chain structure. Full crystallographic information is available from OCA.

See Also

Reference

  • Pazgier M, Liu M, Zou G, Yuan W, Li C, Li C, Li J, Monbo J, Zella D, Tarasov SG, Lu W. Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX. Proc Natl Acad Sci U S A. 2009 Mar 2. PMID:19255450
  1. ↑ Chen L, Gilkes DM, Pan Y, Lane WS, Chen J. ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage. EMBO J. 2005 Oct 5;24(19):3411-22. Epub 2005 Sep 15. PMID:16163388 doi:10.1038/sj.emboj.7600812
  2. ↑ Jin Y, Dai MS, Lu SZ, Xu Y, Luo Z, Zhao Y, Lu H. 14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation. EMBO J. 2006 Mar 22;25(6):1207-18. Epub 2006 Mar 2. PMID:16511572 doi:10.1038/sj.emboj.7601010

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OCA

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