3sp9

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[[Image:3sp9.png|left|200px]]
 
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{{STRUCTURE_3sp9| PDB=3sp9 | SCENE= }}
{{STRUCTURE_3sp9| PDB=3sp9 | SCENE= }}
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===Structural basis for iloprost as a dual PPARalpha/delta agonist===
===Structural basis for iloprost as a dual PPARalpha/delta agonist===
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{{ABSTRACT_PUBMED_21775429}}
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{{ABSTRACT_PUBMED_21775429}}
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==Function==
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[[http://www.uniprot.org/uniprot/PPARD_HUMAN PPARD_HUMAN]] Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.<ref>PMID:1333051</ref> <ref>PMID:15604518</ref>
==About this Structure==
==About this Structure==
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[[3sp9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SP9 OCA].
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[[3sp9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SP9 OCA].
==See Also==
==See Also==
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==Reference==
==Reference==
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<ref group="xtra">PMID:021775429</ref><references group="xtra"/>
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<ref group="xtra">PMID:021775429</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Human]]
[[Category: Li, Y.]]
[[Category: Li, Y.]]
[[Category: Rong, H.]]
[[Category: Rong, H.]]

Revision as of 07:24, 16 April 2014

Template:STRUCTURE 3sp9

Contents

Structural basis for iloprost as a dual PPARalpha/delta agonist

Template:ABSTRACT PUBMED 21775429

Function

[PPARD_HUMAN] Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.[1] [2]

About this Structure

3sp9 is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.

See Also

Reference

  • Jin L, Lin S, Rong H, Zheng S, Jin S, Wang R, Li Y. Structural basis for iloprost as a dual peroxisome proliferator-activated receptor alpha/delta agonist. J Biol Chem. 2011 Sep 9;286(36):31473-9. Epub 2011 Jul 20. PMID:21775429 doi:10.1074/jbc.M111.266023
  1. ↑ Schmidt A, Endo N, Rutledge SJ, Vogel R, Shinar D, Rodan GA. Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids. Mol Endocrinol. 1992 Oct;6(10):1634-41. PMID:1333051 doi:http://dx.doi.org/10.1210/mend.6.10.1333051
  2. ↑ van der Veen JN, Kruit JK, Havinga R, Baller JF, Chimini G, Lestavel S, Staels B, Groot PH, Groen AK, Kuipers F. Reduced cholesterol absorption upon PPARdelta activation coincides with decreased intestinal expression of NPC1L1. J Lipid Res. 2005 Mar;46(3):526-34. Epub 2004 Dec 16. PMID:15604518 doi:http://dx.doi.org/10.1194/jlr.M400400-JLR200

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