1luz
From Proteopedia
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| - | [[Image:1luz.jpg|left|200px]] | + | [[Image:1luz.jpg|left|200px]] |
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| - | '''Crystal Structure of the K3L Protein From Vaccinia Virus (Wisconsin Strain)''' | + | {{Structure |
| + | |PDB= 1luz |SIZE=350|CAPTION= <scene name='initialview01'>1luz</scene>, resolution 1.8Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= K3L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10245 Vaccinia virus]) | ||
| + | }} | ||
| + | |||
| + | '''Crystal Structure of the K3L Protein From Vaccinia Virus (Wisconsin Strain)''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1LUZ is a [ | + | 1LUZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LUZ OCA]. |
==Reference== | ==Reference== | ||
| - | X-ray crystal structure and functional analysis of vaccinia virus K3L reveals molecular determinants for PKR subversion and substrate recognition., Dar AC, Sicheri F, Mol Cell. 2002 Aug;10(2):295-305. PMID:[http:// | + | X-ray crystal structure and functional analysis of vaccinia virus K3L reveals molecular determinants for PKR subversion and substrate recognition., Dar AC, Sicheri F, Mol Cell. 2002 Aug;10(2):295-305. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12191475 12191475] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Vaccinia virus]] | [[Category: Vaccinia virus]] | ||
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[[Category: 5 stranded anti-parallel beta barrel]] | [[Category: 5 stranded anti-parallel beta barrel]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:35:30 2008'' |
Revision as of 10:35, 20 March 2008
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| , resolution 1.8Å | |||||||
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| Gene: | K3L (Vaccinia virus) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of the K3L Protein From Vaccinia Virus (Wisconsin Strain)
Overview
The vaccinia virus protein K3L subverts the mammalian antiviral defense mechanism by inhibiting the RNA-dependent protein kinase PKR. K3L is a structural mimic of PKR's natural substrate, the translation initiation factor eIF2alpha. To further our understanding of K3L inhibitory function and PKR substrate recognition, we have solved the 1.8 A X-ray crystal structure of K3L. The structure consists of a five-strand beta barrel with an intervening helix insert region similar in topology to the functionally divergent S1 domain. Mutational analysis identifies two proximal regions of the K3L structure as possessing specialized PKR binding and inhibitory function. Further analysis reveals that PKR dimerization composes a key switch that regulates both its catalytic activation and its molecular recognition of K3L and eIF2alpha.
About this Structure
1LUZ is a Single protein structure of sequence from Vaccinia virus. Full crystallographic information is available from OCA.
Reference
X-ray crystal structure and functional analysis of vaccinia virus K3L reveals molecular determinants for PKR subversion and substrate recognition., Dar AC, Sicheri F, Mol Cell. 2002 Aug;10(2):295-305. PMID:12191475
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