1lv7
From Proteopedia
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| - | [[Image:1lv7.gif|left|200px]] | + | [[Image:1lv7.gif|left|200px]] |
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| - | '''Crystal Structure of the AAA domain of FtsH''' | + | {{Structure |
| + | |PDB= 1lv7 |SIZE=350|CAPTION= <scene name='initialview01'>1lv7</scene>, resolution 1.50Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= FTSH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli]) | ||
| + | }} | ||
| + | |||
| + | '''Crystal Structure of the AAA domain of FtsH''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1LV7 is a [ | + | 1LV7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LV7 OCA]. |
==Reference== | ==Reference== | ||
| - | The crystal structure of the AAA domain of the ATP-dependent protease FtsH of Escherichia coli at 1.5 A resolution., Krzywda S, Brzozowski AM, Verma C, Karata K, Ogura T, Wilkinson AJ, Structure. 2002 Aug;10(8):1073-83. PMID:[http:// | + | The crystal structure of the AAA domain of the ATP-dependent protease FtsH of Escherichia coli at 1.5 A resolution., Krzywda S, Brzozowski AM, Verma C, Karata K, Ogura T, Wilkinson AJ, Structure. 2002 Aug;10(8):1073-83. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12176385 12176385] |
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: four helix bundle]] | [[Category: four helix bundle]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:35:34 2008'' |
Revision as of 10:35, 20 March 2008
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| , resolution 1.50Å | |||||||
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| Ligands: | |||||||
| Gene: | FTSH (Escherichia coli) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of the AAA domain of FtsH
Overview
Eubacteria and eukaryotic cellular organelles have membrane-bound ATP-dependent proteases, which degrade misassembled membrane protein complexes and play a vital role in membrane quality control. The bacterial protease FtsH also degrades an interesting subset of cytoplasmic regulatory proteins, including sigma(32), LpxC, and lambda CII. The crystal structure of the ATPase module of FtsH has been solved, revealing an alpha/beta nucleotide binding domain connected to a four-helix bundle, similar to the AAA modules of proteins involved in DNA replication and membrane fusion. A sulfate anion in the ATP binding pocket mimics the beta-phosphate group of an adenine nucleotide. A hexamer form of FtsH has been modeled, providing insights into possible modes of nucleotide binding and intersubunit catalysis.
About this Structure
1LV7 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
The crystal structure of the AAA domain of the ATP-dependent protease FtsH of Escherichia coli at 1.5 A resolution., Krzywda S, Brzozowski AM, Verma C, Karata K, Ogura T, Wilkinson AJ, Structure. 2002 Aug;10(8):1073-83. PMID:12176385
Page seeded by OCA on Thu Mar 20 12:35:34 2008
