3fva

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[[Image:3fva.png|left|200px]]
 
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{{STRUCTURE_3fva| PDB=3fva | SCENE= }}
{{STRUCTURE_3fva| PDB=3fva | SCENE= }}
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===NNQNTF segment from elk prion===
===NNQNTF segment from elk prion===
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{{ABSTRACT_PUBMED_19684598}}
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{{ABSTRACT_PUBMED_19684598}}
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==Disease==
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[[http://www.uniprot.org/uniprot/PRIO_CEREN PRIO_CEREN]] Note=PrP is found in high quantity in the brain of humans and animals infected with the degenerative neurological diseases kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
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==Function==
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[[http://www.uniprot.org/uniprot/PRIO_CEREN PRIO_CEREN]] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:019684598</ref><references group="xtra"/>
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<ref group="xtra">PMID:019684598</ref><references group="xtra"/><references/>
[[Category: Apostol, M I.]]
[[Category: Apostol, M I.]]
[[Category: Eisenberg, D.]]
[[Category: Eisenberg, D.]]

Revision as of 11:53, 24 March 2013

Template:STRUCTURE 3fva

Contents

NNQNTF segment from elk prion

Template:ABSTRACT PUBMED 19684598

Disease

[PRIO_CEREN] Note=PrP is found in high quantity in the brain of humans and animals infected with the degenerative neurological diseases kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.

Function

[PRIO_CEREN] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).

About this Structure

3fva is a 1 chain structure. Full crystallographic information is available from OCA.

See Also

Reference

  • Wiltzius JJ, Landau M, Nelson R, Sawaya MR, Apostol MI, Goldschmidt L, Soriaga AB, Cascio D, Rajashankar K, Eisenberg D. Molecular mechanisms for protein-encoded inheritance. Nat Struct Mol Biol. 2009 Sep;16(9):973-8. Epub 2009 Aug 16. PMID:19684598 doi:10.1038/nsmb.1643

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OCA

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