1lw3
From Proteopedia
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| - | [[Image:1lw3.jpg|left|200px]] | + | [[Image:1lw3.jpg|left|200px]] |
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| - | '''Crystal Structure of Myotubularin-related protein 2 complexed with phosphate''' | + | {{Structure |
| + | |PDB= 1lw3 |SIZE=350|CAPTION= <scene name='initialview01'>1lw3</scene>, resolution 2.3Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=PO4:PHOSPHATE ION'>PO4</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Phosphatidylinositol-3-phosphatase Phosphatidylinositol-3-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.64 3.1.3.64] | ||
| + | |GENE= MTMR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''Crystal Structure of Myotubularin-related protein 2 complexed with phosphate''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1LW3 is a [ | + | 1LW3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LW3 OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of a phosphoinositide phosphatase, MTMR2: insights into myotubular myopathy and Charcot-Marie-Tooth syndrome., Begley MJ, Taylor GS, Kim SA, Veine DM, Dixon JE, Stuckey JA, Mol Cell. 2003 Dec;12(6):1391-402. PMID:[http:// | + | Crystal structure of a phosphoinositide phosphatase, MTMR2: insights into myotubular myopathy and Charcot-Marie-Tooth syndrome., Begley MJ, Taylor GS, Kim SA, Veine DM, Dixon JE, Stuckey JA, Mol Cell. 2003 Dec;12(6):1391-402. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14690594 14690594] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Phosphatidylinositol-3-phosphatase]] | [[Category: Phosphatidylinositol-3-phosphatase]] | ||
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[[Category: protein-phosphate complex]] | [[Category: protein-phosphate complex]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:35:53 2008'' |
Revision as of 10:35, 20 March 2008
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| , resolution 2.3Å | |||||||
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| Ligands: | |||||||
| Gene: | MTMR2 (Homo sapiens) | ||||||
| Activity: | Phosphatidylinositol-3-phosphatase, with EC number 3.1.3.64 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of Myotubularin-related protein 2 complexed with phosphate
Contents |
Overview
Myotubularin-related proteins are a large subfamily of protein tyrosine phosphatases (PTPs) that dephosphorylate D3-phosphorylated inositol lipids. Mutations in members of the myotubularin family cause the human neuromuscular disorders myotubular myopathy and type 4B Charcot-Marie-Tooth syndrome. The crystal structure of a representative member of this family, MTMR2, reveals a phosphatase domain that is structurally unique among PTPs. A series of mutants are described that exhibit altered enzymatic activity and provide insight into the specificity of myotubularin phosphatases toward phosphoinositide substrates. The structure also reveals that the GRAM domain, found in myotubularin family phosphatases and predicted to occur in approximately 180 proteins, is part of a larger motif with a pleckstrin homology (PH) domain fold. Finally, the MTMR2 structure will serve as a model for other members of the myotubularin family and provide a framework for understanding the mechanism whereby mutations in these proteins lead to disease.
Disease
Known disease associated with this structure: Charcot-Marie-Tooth disease, type 4B1 OMIM:[603557]
About this Structure
1LW3 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of a phosphoinositide phosphatase, MTMR2: insights into myotubular myopathy and Charcot-Marie-Tooth syndrome., Begley MJ, Taylor GS, Kim SA, Veine DM, Dixon JE, Stuckey JA, Mol Cell. 2003 Dec;12(6):1391-402. PMID:14690594
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