2v8o

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2v8o.png|left|200px]]
+
==STRUCTURE OF THE MURRAY VALLEY ENCEPHALITIS VIRUS RNA HELICASE TO 1.9A RESOLUTION==
 +
<StructureSection load='2v8o' size='340' side='right' caption='[[2v8o]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2v8o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Murray_valley_encephalitis_virus Murray valley encephalitis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V8O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V8O FirstGlance]. <br>
 +
</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Flavivirin Flavivirin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.91 3.4.21.91] </span></td></tr>
 +
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v8o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v8o RCSB], [http://www.ebi.ac.uk/pdbsum/2v8o PDBsum]</span></td></tr>
 +
<table>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v8/2v8o_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Murray Valley encephalitis virus (MVEV), a mosquito-borne flavivirus endemic to Australia, is closely related to Japanese encephalitis virus and West Nile virus. Nonstructural protein 3 (NS3) is a multifunctional enzyme with serine protease and DEXH/D-box helicase domains, whose activity is central to flavivirus replication and is therefore a possible target for anti-flaviviral compounds. Cloning, purification, and crystal structure determination to 1.9 Angstrom resolution of the NS3 helicase of MVEV and characterization of its enzymatic activity is reported. Comparison with the structures of helicases from related viruses supports a possible mechanism of ATP hydrolysis-driven strand separation.
-
{{STRUCTURE_2v8o| PDB=2v8o | SCENE= }}
+
Structure of the Murray Valley encephalitis virus RNA helicase at 1.9 Angstrom resolution.,Mancini EJ, Assenberg R, Verma A, Walter TS, Tuma R, Grimes JM, Owens RJ, Stuart DI Protein Sci. 2007 Oct;16(10):2294-300. PMID:17893366<ref>PMID:17893366</ref>
-
===STRUCTURE OF THE MURRAY VALLEY ENCEPHALITIS VIRUS RNA HELICASE TO 1.9A RESOLUTION===
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
{{ABSTRACT_PUBMED_17893366}}
+
-
 
+
-
==About this Structure==
+
-
[[2v8o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Murray_valley_encephalitis_virus Murray valley encephalitis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V8O OCA].
+
==See Also==
==See Also==
*[[Helicase|Helicase]]
*[[Helicase|Helicase]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:017893366</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
[[Category: Flavivirin]]
[[Category: Flavivirin]]
[[Category: Murray valley encephalitis virus]]
[[Category: Murray valley encephalitis virus]]

Revision as of 08:35, 29 September 2014

STRUCTURE OF THE MURRAY VALLEY ENCEPHALITIS VIRUS RNA HELICASE TO 1.9A RESOLUTION

2v8o, resolution 1.90Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2v8o"
Views
Personal tools
Navigation
Toolbox