1lwu

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[[Image:1lwu.gif|left|200px]]<br /><applet load="1lwu" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1lwu.gif|left|200px]]
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caption="1lwu, resolution 2.80&Aring;" />
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'''Crystal structure of fragment D from lamprey fibrinogen complexed with the peptide Gly-His-Arg-Pro-amide'''<br />
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{{Structure
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|PDB= 1lwu |SIZE=350|CAPTION= <scene name='initialview01'>1lwu</scene>, resolution 2.80&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=NH2:AMINO GROUP'>NH2</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Crystal structure of fragment D from lamprey fibrinogen complexed with the peptide Gly-His-Arg-Pro-amide'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1LWU is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Petromyzon_marinus Petromyzon marinus] with <scene name='pdbligand=NDG:'>NDG</scene>, <scene name='pdbligand=MAN:'>MAN</scene>, <scene name='pdbligand=NAG:'>NAG</scene>, <scene name='pdbligand=GAL:'>GAL</scene>, <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=NH2:'>NH2</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LWU OCA].
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1LWU is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Petromyzon_marinus Petromyzon marinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LWU OCA].
==Reference==
==Reference==
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Crystal structure of fragment D from lamprey fibrinogen complexed with the peptide Gly-His-Arg-Pro-amide., Yang Z, Spraggon G, Pandi L, Everse SJ, Riley M, Doolittle RF, Biochemistry. 2002 Aug 13;41(32):10218-24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12162736 12162736]
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Crystal structure of fragment D from lamprey fibrinogen complexed with the peptide Gly-His-Arg-Pro-amide., Yang Z, Spraggon G, Pandi L, Everse SJ, Riley M, Doolittle RF, Biochemistry. 2002 Aug 13;41(32):10218-24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12162736 12162736]
[[Category: Petromyzon marinus]]
[[Category: Petromyzon marinus]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: protein-peptide complex]]
[[Category: protein-peptide complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:49:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:36:11 2008''

Revision as of 10:36, 20 March 2008

Image:1lwu.gif


PDB ID 1lwu

Drag the structure with the mouse to rotate
, resolution 2.80Å
Ligands: , , , , and
Coordinates: save as pdb, mmCIF, xml



Crystal structure of fragment D from lamprey fibrinogen complexed with the peptide Gly-His-Arg-Pro-amide


Overview

The crystal structure of fragment D from lamprey fibrinogen has been determined at 2.8 A resolution. The 89 kDa protein was cocrystallized with the peptide Gly-His-Arg-Pro-amide, which in many fibrinogens-but not lamprey-corresponds to the B knob exposed by thrombin. Because lamprey fragment D is more than 50% identical in sequence with human fragment D, the structure of which has been reported previously, it was possible to use the method of molecular replacement. The space group of the lamprey crystals is P1; there are four molecules in the unit cell. Although the fragments are packed head to head by the same D:D interface as is observed in other related preparations containing fragments D, the tails are uniquely joined by an unnatural association of the terminal sections of the residual coiled coils from adjacent molecules. Some features of the lamprey structure are clearer than have been observed in previous fragment D structures, including the beta-chain carbohydrate cluster, for one, and the important gamma-chain carboxyl-terminal segment, for another. The most significant differences between the lamprey and human structures occur in connecting loops at the entryways to the beta-chain and gamma-chain binding pockets.

About this Structure

1LWU is a Protein complex structure of sequences from Petromyzon marinus. Full crystallographic information is available from OCA.

Reference

Crystal structure of fragment D from lamprey fibrinogen complexed with the peptide Gly-His-Arg-Pro-amide., Yang Z, Spraggon G, Pandi L, Everse SJ, Riley M, Doolittle RF, Biochemistry. 2002 Aug 13;41(32):10218-24. PMID:12162736

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