1n4m

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[[Image:1n4m.png|left|200px]]
 
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{{STRUCTURE_1n4m| PDB=1n4m | SCENE= }}
{{STRUCTURE_1n4m| PDB=1n4m | SCENE= }}
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===Structure of Rb tumor suppressor bound to the transactivation domain of E2F-2===
===Structure of Rb tumor suppressor bound to the transactivation domain of E2F-2===
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{{ABSTRACT_PUBMED_12502741}}
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{{ABSTRACT_PUBMED_12502741}}
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==Function==
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[[http://www.uniprot.org/uniprot/E2F2_HUMAN E2F2_HUMAN]] Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner.
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:012502741</ref><references group="xtra"/>
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<ref group="xtra">PMID:012502741</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Chang, J H.]]
[[Category: Chang, J H.]]

Revision as of 17:22, 24 March 2013

Template:STRUCTURE 1n4m

Contents

Structure of Rb tumor suppressor bound to the transactivation domain of E2F-2

Template:ABSTRACT PUBMED 12502741

Function

[E2F2_HUMAN] Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner.

About this Structure

1n4m is a 5 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Lee C, Chang JH, Lee HS, Cho Y. Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor. Genes Dev. 2002 Dec 15;16(24):3199-212. PMID:12502741 doi:10.1101/gad.1046102

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OCA

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