1h8d
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | [[Image:1h8d.png|left|200px]] | ||
| - | |||
{{STRUCTURE_1h8d| PDB=1h8d | SCENE= }} | {{STRUCTURE_1h8d| PDB=1h8d | SCENE= }} | ||
| - | + | ===X-ray structure of the human alpha-thrombin complex with a tripeptide phosphonate inhibitor.=== | |
| - | ===X- | + | |
| - | + | ||
{{ABSTRACT_PUBMED_11493008}} | {{ABSTRACT_PUBMED_11493008}} | ||
| Line 19: | Line 15: | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Thrombin]] | [[Category: Thrombin]] | ||
| - | [[Category: Deadman, | + | [[Category: Deadman, J.]] |
[[Category: Dodson, G G.]] | [[Category: Dodson, G G.]] | ||
| - | [[Category: Green, D | + | [[Category: Green, D.]] |
[[Category: Skordalakes, E.]] | [[Category: Skordalakes, E.]] | ||
[[Category: Hydrolase-hydrolase inhibitor complex]] | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
[[Category: Serine protease]] | [[Category: Serine protease]] | ||
Revision as of 09:01, 13 March 2013
Contents |
X-ray structure of the human alpha-thrombin complex with a tripeptide phosphonate inhibitor.
Template:ABSTRACT PUBMED 11493008
About this Structure
1h8d is a 3 chain structure with sequence from Hirudo medicinalis and Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Skordalakes E, Dodson GG, Green DS, Goodwin CA, Scully MF, Hudson HR, Kakkar VV, Deadman JJ. Inhibition of human alpha-thrombin by a phosphonate tripeptide proceeds via a metastable pentacoordinated phosphorus intermediate. J Mol Biol. 2001 Aug 17;311(3):549-55. PMID:11493008 doi:10.1006/jmbi.2001.4872
- Bertrand JA, Oleksyszyn J, Kam CM, Boduszek B, Presnell S, Plaskon RR, Suddath FL, Powers JC, Williams LD. Inhibition of trypsin and thrombin by amino(4-amidinophenyl)methanephosphonate diphenyl ester derivatives: X-ray structures and molecular models. Biochemistry. 1996 Mar 12;35(10):3147-55. PMID:8605148 doi:http://dx.doi.org/10.1021/bi9520996
