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1h8d

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[[Image:1h8d.png|left|200px]]
 
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{{STRUCTURE_1h8d| PDB=1h8d | SCENE= }}
{{STRUCTURE_1h8d| PDB=1h8d | SCENE= }}
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===X-ray structure of the human alpha-thrombin complex with a tripeptide phosphonate inhibitor.===
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===X-RAY STRUCTURE OF THE HUMAN ALPHA-THROMBIN COMPLEX WITH A TRIPEPTIDE PHOSPHONATE INHIBITOR.===
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{{ABSTRACT_PUBMED_11493008}}
{{ABSTRACT_PUBMED_11493008}}
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Thrombin]]
[[Category: Thrombin]]
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[[Category: Deadman, J J.]]
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[[Category: Deadman, J.]]
[[Category: Dodson, G G.]]
[[Category: Dodson, G G.]]
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[[Category: Green, D S.]]
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[[Category: Green, D.]]
[[Category: Skordalakes, E.]]
[[Category: Skordalakes, E.]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Serine protease]]
[[Category: Serine protease]]

Revision as of 09:01, 13 March 2013

Template:STRUCTURE 1h8d

Contents

X-ray structure of the human alpha-thrombin complex with a tripeptide phosphonate inhibitor.

Template:ABSTRACT PUBMED 11493008

About this Structure

1h8d is a 3 chain structure with sequence from Hirudo medicinalis and Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Skordalakes E, Dodson GG, Green DS, Goodwin CA, Scully MF, Hudson HR, Kakkar VV, Deadman JJ. Inhibition of human alpha-thrombin by a phosphonate tripeptide proceeds via a metastable pentacoordinated phosphorus intermediate. J Mol Biol. 2001 Aug 17;311(3):549-55. PMID:11493008 doi:10.1006/jmbi.2001.4872
  • Bertrand JA, Oleksyszyn J, Kam CM, Boduszek B, Presnell S, Plaskon RR, Suddath FL, Powers JC, Williams LD. Inhibition of trypsin and thrombin by amino(4-amidinophenyl)methanephosphonate diphenyl ester derivatives: X-ray structures and molecular models. Biochemistry. 1996 Mar 12;35(10):3147-55. PMID:8605148 doi:http://dx.doi.org/10.1021/bi9520996

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OCA

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