1nwt

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[[Image:1nwt.png|left|200px]]
 
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{{STRUCTURE_1nwt| PDB=1nwt | SCENE= }}
{{STRUCTURE_1nwt| PDB=1nwt | SCENE= }}
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===Crystal structure of human cartilage gp39 (HC-gp39) in complex with chitopentaose===
===Crystal structure of human cartilage gp39 (HC-gp39) in complex with chitopentaose===
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{{ABSTRACT_PUBMED_12851408}}
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{{ABSTRACT_PUBMED_12851408}}
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==Disease==
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[[http://www.uniprot.org/uniprot/CH3L1_HUMAN CH3L1_HUMAN]] A genetic variation in CHI3L1 is associated with susceptibility to asthma-related traits type 7 (ASRT7) [MIM:[http://omim.org/entry/611960 611960]]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing and dyspnea, bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis.
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==Function==
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[[http://www.uniprot.org/uniprot/CH3L1_HUMAN CH3L1_HUMAN]] Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens, or in tissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes in their environment.<ref>PMID:9492324</ref>
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:012851408</ref><references group="xtra"/>
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<ref group="xtra">PMID:012851408</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bos, E.]]
[[Category: Bos, E.]]

Revision as of 17:56, 24 March 2013

Template:STRUCTURE 1nwt

Contents

Crystal structure of human cartilage gp39 (HC-gp39) in complex with chitopentaose

Template:ABSTRACT PUBMED 12851408

Disease

[CH3L1_HUMAN] A genetic variation in CHI3L1 is associated with susceptibility to asthma-related traits type 7 (ASRT7) [MIM:611960]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing and dyspnea, bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis.

Function

[CH3L1_HUMAN] Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens, or in tissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes in their environment.[1]

About this Structure

1nwt is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Fusetti F, Pijning T, Kalk KH, Bos E, Dijkstra BW. Crystal structure and carbohydrate-binding properties of the human cartilage glycoprotein-39. J Biol Chem. 2003 Sep 26;278(39):37753-60. Epub 2003 Jul 8. PMID:12851408 doi:http://dx.doi.org/10.1074/jbc.M303137200
  1. ↑ Renkema GH, Boot RG, Au FL, Donker-Koopman WE, Strijland A, Muijsers AO, Hrebicek M, Aerts JM. Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages. Eur J Biochem. 1998 Jan 15;251(1-2):504-9. PMID:9492324

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