1m1j

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[[Image:1m1j.gif|left|200px]]<br /><applet load="1m1j" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1m1j.gif|left|200px]]
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caption="1m1j, resolution 2.70&Aring;" />
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'''Crystal structure of native chicken fibrinogen with two different bound ligands'''<br />
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{{Structure
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|PDB= 1m1j |SIZE=350|CAPTION= <scene name='initialview01'>1m1j</scene>, resolution 2.70&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> and <scene name='pdbligand=CA:CALCIUM ION'>CA</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Crystal structure of native chicken fibrinogen with two different bound ligands'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1M1J is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with <scene name='pdbligand=NDG:'>NDG</scene>, <scene name='pdbligand=NAG:'>NAG</scene> and <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. This structure supersedes the now removed PDB entry 1JFE. The following page contains interesting information on the relation of 1M1J with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb83_1.html Fibrin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M1J OCA].
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1M1J is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. This structure supersedes the now removed PDB entry 1JFE. The following page contains interesting information on the relation of 1M1J with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb83_1.html Fibrin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M1J OCA].
==Reference==
==Reference==
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Crystal structure of native chicken fibrinogen at 2.7 A resolution., Yang Z, Kollman JM, Pandi L, Doolittle RF, Biochemistry. 2001 Oct 23;40(42):12515-23. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11601975 11601975]
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Crystal structure of native chicken fibrinogen at 2.7 A resolution., Yang Z, Kollman JM, Pandi L, Doolittle RF, Biochemistry. 2001 Oct 23;40(42):12515-23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11601975 11601975]
[[Category: Fibrin]]
[[Category: Fibrin]]
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
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[[Category: NAG]]
[[Category: NAG]]
[[Category: NDG]]
[[Category: NDG]]
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[[Category: coiled coils]]
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[[Category: coiled coil]]
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[[Category: disulfide rings]]
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[[Category: disulfide ring]]
[[Category: fibrinogen]]
[[Category: fibrinogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:50:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:37:43 2008''

Revision as of 10:37, 20 March 2008

Image:1m1j.gif


PDB ID 1m1j

Drag the structure with the mouse to rotate
, resolution 2.70Å
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



Crystal structure of native chicken fibrinogen with two different bound ligands


Overview

The crystal structure of native chicken fibrinogen (320 kDa) complexed with two synthetic peptides has been determined at a resolution of 2.7 A. The structure provides the first atomic-resolution view of the polypeptide chain arrangement in the central domain where the two halves of the molecule are joined, as well as of a putative thrombin-binding site. The amino-terminal segments of the alpha and beta chains, including fibrinopeptides A and B, are not visible in electron density maps, however, and must be highly disordered. The alphaC domain is also very disordered. A residue by residue analysis of the coiled coils with regard to temperature factor shows a strong correlation between mobility and plasmin attack sites. It is concluded that structural flexibility is an inherent feature of fibrinogen that plays a key role in both its conversion to fibrin and its subsequent destruction by plasmin.

About this Structure

1M1J is a Protein complex structure of sequences from Gallus gallus. This structure supersedes the now removed PDB entry 1JFE. The following page contains interesting information on the relation of 1M1J with [Fibrin]. Full crystallographic information is available from OCA.

Reference

Crystal structure of native chicken fibrinogen at 2.7 A resolution., Yang Z, Kollman JM, Pandi L, Doolittle RF, Biochemistry. 2001 Oct 23;40(42):12515-23. PMID:11601975

Page seeded by OCA on Thu Mar 20 12:37:43 2008

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