2ztn

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[[Image:2ztn.png|left|200px]]
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==Hepatitis E virus ORF2 (Genotype 3)==
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<StructureSection load='2ztn' size='340' side='right' caption='[[2ztn]], [[Resolution|resolution]] 3.56&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ztn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_e_virus Hepatitis e virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZTN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZTN FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ztn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ztn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ztn RCSB], [http://www.ebi.ac.uk/pdbsum/2ztn PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Hepatitis E virus (HEV) is a causative agent of acute hepatitis. The crystal structure of HEV-like particles (HEV-LP) consisting of capsid protein was determined at 3.5-A resolution. The capsid protein exhibited a quite different folding at the protruding and middle domains from the members of the families of Caliciviridae and Tombusviridae, while the shell domain shared the common folding. Tyr-288 at the 5-fold axis plays key roles in the assembly of HEV-LP, and aromatic amino acid residues are well conserved among the structurally related viruses. Mutational analyses indicated that the protruding domain is involved in the binding to the cells susceptive to HEV infection and has some neutralization epitopes. These structural and biological findings are important for understanding the molecular mechanisms of assembly and entry of HEV and also provide clues in the development of preventive and prophylactic measures for hepatitis E.
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{{STRUCTURE_2ztn| PDB=2ztn | SCENE= }}
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Biological and immunological characteristics of hepatitis E virus-like particles based on the crystal structure.,Yamashita T, Mori Y, Miyazaki N, Cheng RH, Yoshimura M, Unno H, Shima R, Moriishi K, Tsukihara T, Li TC, Takeda N, Miyamura T, Matsuura Y Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12986-91. Epub 2009 Jul 20. PMID:19620712<ref>PMID:19620712</ref>
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===Hepatitis E virus ORF2 (Genotype 3)===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_19620712}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2ztn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_e_virus Hepatitis e virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZTN OCA].
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</StructureSection>
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==See Also==
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*[[Virus coat protein|Virus coat protein]]
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==Reference==
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<ref group="xtra">PMID:019620712</ref><references group="xtra"/>
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[[Category: Hepatitis e virus]]
[[Category: Hepatitis e virus]]
[[Category: Li, T C.]]
[[Category: Li, T C.]]

Revision as of 11:51, 29 October 2014

Hepatitis E virus ORF2 (Genotype 3)

2ztn, resolution 3.56Å

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