1m2e
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:1m2e.jpg|left|200px]] | + | [[Image:1m2e.jpg|left|200px]] |
| - | + | ||
| - | '''Solution structure of the N-terminal domain of Synechococcus elongatus KaiA (KaiA135N); Average minimized structure.''' | + | {{Structure |
| + | |PDB= 1m2e |SIZE=350|CAPTION= <scene name='initialview01'>1m2e</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= kaiA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32046 Synechococcus elongatus]) | ||
| + | }} | ||
| + | |||
| + | '''Solution structure of the N-terminal domain of Synechococcus elongatus KaiA (KaiA135N); Average minimized structure.''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1M2E is a [ | + | 1M2E is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Synechococcus_elongatus Synechococcus elongatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M2E OCA]. |
==Reference== | ==Reference== | ||
| - | Structure and function from the circadian clock protein KaiA of Synechococcus elongatus: a potential clock input mechanism., Williams SB, Vakonakis I, Golden SS, LiWang AC, Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15357-62. Epub 2002 Nov 15. PMID:[http:// | + | Structure and function from the circadian clock protein KaiA of Synechococcus elongatus: a potential clock input mechanism., Williams SB, Vakonakis I, Golden SS, LiWang AC, Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15357-62. Epub 2002 Nov 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12438647 12438647] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Synechococcus elongatus]] | [[Category: Synechococcus elongatus]] | ||
| Line 19: | Line 28: | ||
[[Category: alpha-beta-alpha sandwich]] | [[Category: alpha-beta-alpha sandwich]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:38:02 2008'' |
Revision as of 10:38, 20 March 2008
| |||||||
| Gene: | kaiA (Synechococcus elongatus) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution structure of the N-terminal domain of Synechococcus elongatus KaiA (KaiA135N); Average minimized structure.
Overview
In the cyanobacterium Synechococcus elongatus (PCC 7942) the proteins KaiA, KaiB, and KaiC are required for circadian clock function. We deduced a circadian clock function for KaiA from a combination of biochemical and structural data. Both KaiA and its isolated carboxyl-terminal domain (KaiA180C) stimulated KaiC autophosphorylation and facilitated attenuation of KaiC autophosphorylation by KaiB. An amino-terminal domain (KaiA135N) had no function in the autophosphorylation assay. NMR structure determination showed that KaiA135N is a pseudo-receiver domain. We propose that this pseudo-receiver is a timing input-device that regulates KaiA stimulation of KaiC autophosphorylation, which in turn is essential for circadian timekeeping.
About this Structure
1M2E is a Single protein structure of sequence from Synechococcus elongatus. Full crystallographic information is available from OCA.
Reference
Structure and function from the circadian clock protein KaiA of Synechococcus elongatus: a potential clock input mechanism., Williams SB, Vakonakis I, Golden SS, LiWang AC, Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15357-62. Epub 2002 Nov 15. PMID:12438647
Page seeded by OCA on Thu Mar 20 12:38:02 2008
