1m5o

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[[Image:1m5o.gif|left|200px]]<br /><applet load="1m5o" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1m5o.gif|left|200px]]
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caption="1m5o, resolution 2.20&Aring;" />
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'''Transition State Stabilization by a Catalytic RNA'''<br />
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{{Structure
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|PDB= 1m5o |SIZE=350|CAPTION= <scene name='initialview01'>1m5o</scene>, resolution 2.20&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene>
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|ACTIVITY=
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|GENE= SNRPA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''Transition State Stabilization by a Catalytic RNA'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1M5O is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M5O OCA].
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1M5O is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M5O OCA].
==Reference==
==Reference==
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Transition state stabilization by a catalytic RNA., Rupert PB, Massey AP, Sigurdsson ST, Ferre-D'Amare AR, Science. 2002 Nov 15;298(5597):1421-4. Epub 2002 Oct 10. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12376595 12376595]
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Transition state stabilization by a catalytic RNA., Rupert PB, Massey AP, Sigurdsson ST, Ferre-D'Amare AR, Science. 2002 Nov 15;298(5597):1421-4. Epub 2002 Oct 10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12376595 12376595]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: vandate]]
[[Category: vandate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:51:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:39:12 2008''

Revision as of 10:39, 20 March 2008

Image:1m5o.gif


PDB ID 1m5o

Drag the structure with the mouse to rotate
, resolution 2.20Å
Ligands:
Gene: SNRPA (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



Transition State Stabilization by a Catalytic RNA


Overview

The hairpin ribozyme catalyzes sequence-specific cleavage of RNA through transesterification of the scissile phosphate. Vanadate has previously been used as a transition state mimic of protein enzymes that catalyze the same reaction. Comparison of the 2.2 angstrom resolution structure of a vanadate-hairpin ribozyme complex with structures of precursor and product complexes reveals a rigid active site that makes more hydrogen bonds to the transition state than to the precursor or product. Because of the paucity of RNA functional groups capable of general acid-base or electrostatic catalysis, transition state stabilization is likely to be an important catalytic strategy for ribozymes.

About this Structure

1M5O is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Transition state stabilization by a catalytic RNA., Rupert PB, Massey AP, Sigurdsson ST, Ferre-D'Amare AR, Science. 2002 Nov 15;298(5597):1421-4. Epub 2002 Oct 10. PMID:12376595

Page seeded by OCA on Thu Mar 20 12:39:12 2008

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