1m6b
From Proteopedia
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| - | [[Image:1m6b.jpg|left|200px]] | + | [[Image:1m6b.jpg|left|200px]] |
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| - | '''Structure of the HER3 (ERBB3) Extracellular Domain''' | + | {{Structure |
| + | |PDB= 1m6b |SIZE=350|CAPTION= <scene name='initialview01'>1m6b</scene>, resolution 2.60Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene> and <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Structure of the HER3 (ERBB3) Extracellular Domain''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1M6B is a [ | + | 1M6B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M6B OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of the extracellular region of HER3 reveals an interdomain tether., Cho HS, Leahy DJ, Science. 2002 Aug 23;297(5585):1330-3. Epub 2002 Aug 1. PMID:[http:// | + | Structure of the extracellular region of HER3 reveals an interdomain tether., Cho HS, Leahy DJ, Science. 2002 Aug 23;297(5585):1330-3. Epub 2002 Aug 1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12154198 12154198] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: tyrosine kinase; cell surface receptor; immunity]] | [[Category: tyrosine kinase; cell surface receptor; immunity]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:39:27 2008'' |
Revision as of 10:39, 20 March 2008
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| , resolution 2.60Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , and | ||||||
| Activity: | Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of the HER3 (ERBB3) Extracellular Domain
Contents |
Overview
We have determined the 2.6 angstrom crystal structure of the entire extracellular region of human HER3 (ErbB3), a member of the epidermal growth factor receptor (EGFR) family. The structure consists of four domains with structural homology to domains found in the type I insulin-like growth factor receptor. The HER3 structure reveals a contact between domains II and IV that constrains the relative orientations of ligand-binding domains and provides a structural basis for understanding both multiple-affinity forms of EGFRs and conformational changes induced in the receptor by ligand binding during signaling. These results also suggest new therapeutic approaches to modulating the behavior of members of the EGFR family.
Disease
Known disease associated with this structure: Lethal congenital contractural syndrome 2 OMIM:[190151]
About this Structure
1M6B is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of the extracellular region of HER3 reveals an interdomain tether., Cho HS, Leahy DJ, Science. 2002 Aug 23;297(5585):1330-3. Epub 2002 Aug 1. PMID:12154198
Page seeded by OCA on Thu Mar 20 12:39:27 2008
