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3e77

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[[Image:3e77.png|left|200px]]
 
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{{STRUCTURE_3e77| PDB=3e77 | SCENE= }}
{{STRUCTURE_3e77| PDB=3e77 | SCENE= }}
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===Human phosphoserine aminotransferase in complex with PLP===
===Human phosphoserine aminotransferase in complex with PLP===
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==Disease==
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[[http://www.uniprot.org/uniprot/SERC_HUMAN SERC_HUMAN]] Defects in PSAT1 are the cause of phosphoserine aminotransferase deficiency (PSATD) [MIM:[http://omim.org/entry/610992 610992]]. PSATD is characterized biochemically by low plasma and cerebrospinal fluid concentrations of serine and glycine and clinically by intractable seizures, acquired microcephaly, hypertonia, and psychomotor retardation.<ref>PMID:17436247</ref>
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==Function==
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[[http://www.uniprot.org/uniprot/SERC_HUMAN SERC_HUMAN]] Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine (By similarity).
==About this Structure==
==About this Structure==
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==See Also==
==See Also==
*[[Phosphoserine aminotransferase|Phosphoserine aminotransferase]]
*[[Phosphoserine aminotransferase|Phosphoserine aminotransferase]]
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==Reference==
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<references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Phosphoserine transaminase]]
[[Category: Phosphoserine transaminase]]

Revision as of 21:58, 24 March 2013

Template:STRUCTURE 3e77

Contents

Human phosphoserine aminotransferase in complex with PLP

Disease

[SERC_HUMAN] Defects in PSAT1 are the cause of phosphoserine aminotransferase deficiency (PSATD) [MIM:610992]. PSATD is characterized biochemically by low plasma and cerebrospinal fluid concentrations of serine and glycine and clinically by intractable seizures, acquired microcephaly, hypertonia, and psychomotor retardation.[1]

Function

[SERC_HUMAN] Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine (By similarity).

About this Structure

3e77 is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. ↑ Hart CE, Race V, Achouri Y, Wiame E, Sharrard M, Olpin SE, Watkinson J, Bonham JR, Jaeken J, Matthijs G, Van Schaftingen E. Phosphoserine aminotransferase deficiency: a novel disorder of the serine biosynthesis pathway. Am J Hum Genet. 2007 May;80(5):931-7. Epub 2007 Mar 30. PMID:17436247 doi:S0002-9297(07)60948-3

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OCA

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