1h7n
From Proteopedia
(New page: 200px<br /> <applet load="1h7n" size="450" color="white" frame="true" align="right" spinBox="true" caption="1h7n, resolution 1.6Å" /> '''SCHIFF-BASE COMPLEX ...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1H7N is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]] with ZN and SHF as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.24 4.2.1.24]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H7N OCA]]. | + | 1H7N is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]] with ZN and SHF as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Lyase Lyase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.24 4.2.1.24]]. Structure known Active Sites: AC1 and AC2. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H7N OCA]]. |
==Reference== | ==Reference== | ||
| Line 29: | Line 29: | ||
[[Category: tim barrel]] | [[Category: tim barrel]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:31:59 2007'' |
Revision as of 06:27, 30 October 2007
|
SCHIFF-BASE COMPLEX OF YEAST 5-AMINOLAEVULINIC ACID DEHYDRATASE WITH LAEVULINIC ACID AT 1.6 A RESOLUTION
Overview
The structures of 5-aminolaevulinic acid dehydratase (ALAD) complexed with, substrate (5-aminolaevulinic acid) and three inhibitors: laevulinic acid, succinylacetone and 4-keto-5-aminolaevulinic acid, have been solved at, high resolution. The ligands all bind by forming a covalent link with, Lys263 at the active site. The structures define the interactions made by, one of the two substrate moieties that bind to the enzyme during, catalysis. All of the inhibitors induce a significant ordering of the flap, covering the active site. Succinylacetone appears to be unique by inducing, a number of conformational changes in loops covering the active site, which may be important for understanding the co-operative properties of, ALAD enzymes. Succinylacetone is produced in large amounts by ... [(full description)]
About this Structure
1H7N is a [Single protein] structure of sequence from [Saccharomyces cerevisiae] with ZN and SHF as [ligands]. Active as [Lyase], with EC number [4.2.1.24]. Structure known Active Sites: AC1 and AC2. Full crystallographic information is available from [OCA].
Reference
The x-ray structure of yeast 5-aminolaevulinic acid dehydratase complexed with substrate and three inhibitors., Erskine PT, Newbold R, Brindley AA, Wood SP, Shoolingin-Jordan PM, Warren MJ, Cooper JB, J Mol Biol. 2001 Sep 7;312(1):133-41. PMID:11545591
Page seeded by OCA on Tue Oct 30 08:31:59 2007
