1m7l
From Proteopedia
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| - | [[Image:1m7l.jpg|left|200px]] | + | [[Image:1m7l.jpg|left|200px]] |
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| - | '''Solution Structure of the Coiled-Coil Trimerization Domain from Lung Surfactant Protein D''' | + | {{Structure |
| + | |PDB= 1m7l |SIZE=350|CAPTION= <scene name='initialview01'>1m7l</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''Solution Structure of the Coiled-Coil Trimerization Domain from Lung Surfactant Protein D''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1M7L is a [ | + | 1M7L is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M7L OCA]. |
==Reference== | ==Reference== | ||
| - | Solution structure of the coiled-coil trimerization domain from lung surfactant protein D., Kovacs H, O'Ddonoghue SI, Hoppe HJ, Comfort D, Reid KB, Campbell D, Nilges M, J Biomol NMR. 2002 Oct;24(2):89-102. PMID:[http:// | + | Solution structure of the coiled-coil trimerization domain from lung surfactant protein D., Kovacs H, O'Ddonoghue SI, Hoppe HJ, Comfort D, Reid KB, Campbell D, Nilges M, J Biomol NMR. 2002 Oct;24(2):89-102. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12495025 12495025] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: Nilges, M.]] | [[Category: Nilges, M.]] | ||
[[Category: Reid, K B.M.]] | [[Category: Reid, K B.M.]] | ||
| - | [[Category: ambiguous distance | + | [[Category: ambiguous distance restraint]] |
[[Category: coiled coil]] | [[Category: coiled coil]] | ||
[[Category: lung surfactant protein]] | [[Category: lung surfactant protein]] | ||
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[[Category: trimer]] | [[Category: trimer]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:39:58 2008'' |
Revision as of 10:39, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution Structure of the Coiled-Coil Trimerization Domain from Lung Surfactant Protein D
Overview
Surfactant protein D (SP-D) is one of four known protein components of the pulmonary surfactant lining the lung alveoli. It is involved in immune and allergic responses. SP-D occurs as a tetramer of trimers. Trimerization is thought to be initiated by a coiled coil domain. We have determined the solution structure of a 64-residue peptide encompassing the coiled coil domain of human SP-D. As predicted, the domain forms a triple-helical parallel coiled coil. As with all symmetric oligomers, the structure calculation was complicated by the symmetry degeneracy in the NMR spectra. We used the symmetry-ADR (ambiguous distance restraint) structure calculation method to solve the structure. The results demonstrate that the leucine zipper region of SP-D is an autonomously folded domain. The structure is very similar to the independently determined X-ray crystal structure, differing mainly at a single residue, Tyr248. This residue is completely symmetric in the solution structure, and markedly asymmetric in the crystalline phase. This difference may be functionally important, as it affects the orientation of the antigenic surface presented by SP-D.
About this Structure
1M7L is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure of the coiled-coil trimerization domain from lung surfactant protein D., Kovacs H, O'Ddonoghue SI, Hoppe HJ, Comfort D, Reid KB, Campbell D, Nilges M, J Biomol NMR. 2002 Oct;24(2):89-102. PMID:12495025
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