This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1syl
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:1syl.png|left|200px]] | ||
| - | |||
{{STRUCTURE_1syl| PDB=1syl | SCENE= }} | {{STRUCTURE_1syl| PDB=1syl | SCENE= }} | ||
| - | |||
===Crystal structure of inactive mutant dUTPase complexed with substrate dUTP=== | ===Crystal structure of inactive mutant dUTPase complexed with substrate dUTP=== | ||
| + | {{ABSTRACT_PUBMED_15208312}} | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/DUT_ECOLI DUT_ECOLI]] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.[HAMAP-Rule:MF_00116] | ||
==About this Structure== | ==About this Structure== | ||
| Line 14: | Line 13: | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:015208312</ref>< | + | <ref group="xtra">PMID:015208312</ref><references group="xtra"/><references/> |
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: DUTP diphosphatase]] | [[Category: DUTP diphosphatase]] | ||
Revision as of 02:42, 20 September 2013
Contents |
Crystal structure of inactive mutant dUTPase complexed with substrate dUTP
Template:ABSTRACT PUBMED 15208312
Function
[DUT_ECOLI] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.[HAMAP-Rule:MF_00116]
About this Structure
1syl is a 1 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.
See Also
Reference
- Barabas O, Pongracz V, Kovari J, Wilmanns M, Vertessy BG. Structural insights into the catalytic mechanism of phosphate ester hydrolysis by dUTPase. J Biol Chem. 2004 Oct 8;279(41):42907-15. Epub 2004 Jun 17. PMID:15208312 doi:10.1074/jbc.M406135200
