1yb1
From Proteopedia
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| - | [[Image:1yb1.png|left|200px]] | ||
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{{STRUCTURE_1yb1| PDB=1yb1 | SCENE= }} | {{STRUCTURE_1yb1| PDB=1yb1 | SCENE= }} | ||
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===Crystal structure of human 17-beta-hydroxysteroid dehydrogenase type XI=== | ===Crystal structure of human 17-beta-hydroxysteroid dehydrogenase type XI=== | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/DHB11_HUMAN DHB11_HUMAN]] Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma. | ||
==About this Structure== | ==About this Structure== | ||
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==See Also== | ==See Also== | ||
*[[Hydroxysteroid dehydrogenase|Hydroxysteroid dehydrogenase]] | *[[Hydroxysteroid dehydrogenase|Hydroxysteroid dehydrogenase]] | ||
| - | [[Category: | + | [[Category: 17-beta-estradiol 17-dehydrogenase]] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith, C.]] | [[Category: Arrowsmith, C.]] | ||
Revision as of 12:41, 3 July 2013
Contents |
Crystal structure of human 17-beta-hydroxysteroid dehydrogenase type XI
Function
[DHB11_HUMAN] Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.
About this Structure
1yb1 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Categories: 17-beta-estradiol 17-dehydrogenase | Homo sapiens | Arrowsmith, C. | Bray, J. | Bunkoczi, G. | Delft, F Von. | Edwards, A. | Kavanagh, K. | Lukacik, P. | Ng, S. | Oppermann, U. | SGC, Structural Genomics Consortium. | Sundstrom, M. | Human | Hydroxysteroid dehydrogenase | Oxidoreductase | Sgc | Short chain dehydrogenase | Structural genomic | Structural genomics consortium
