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1mem

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[[Image:1mem.gif|left|200px]]<br /><applet load="1mem" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1mem.gif|left|200px]]
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caption="1mem, resolution 1.8&Aring;" />
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'''CRYSTAL STRUCTURE OF CATHEPSIN K COMPLEXED WITH A POTENT VINYL SULFONE INHIBITOR'''<br />
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{{Structure
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|PDB= 1mem |SIZE=350|CAPTION= <scene name='initialview01'>1mem</scene>, resolution 1.8&Aring;
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|SITE= <scene name='pdbsite=CAT:Description+Not+Provided'>CAT</scene>
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|LIGAND= <scene name='pdbligand=BZP:N1-CARBOXYPIPERAZINE'>BZP</scene> and <scene name='pdbligand=BNS:HYDROSULFONYLBENZENE'>BNS</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38]
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF CATHEPSIN K COMPLEXED WITH A POTENT VINYL SULFONE INHIBITOR'''
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==Disease==
==Disease==
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==About this Structure==
==About this Structure==
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1MEM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=BZP:'>BZP</scene> and <scene name='pdbligand=BNS:'>BNS</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] Known structural/functional Site: <scene name='pdbsite=CAT:Description+Not+Provided'>CAT</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MEM OCA].
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1MEM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MEM OCA].
==Reference==
==Reference==
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Crystal structure of human cathepsin K complexed with a potent inhibitor., McGrath ME, Klaus JL, Barnes MG, Bromme D, Nat Struct Biol. 1997 Feb;4(2):105-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9033587 9033587]
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Crystal structure of human cathepsin K complexed with a potent inhibitor., McGrath ME, Klaus JL, Barnes MG, Bromme D, Nat Struct Biol. 1997 Feb;4(2):105-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9033587 9033587]
[[Category: Cathepsin K]]
[[Category: Cathepsin K]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: protease]]
[[Category: protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:54:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:42:32 2008''

Revision as of 10:42, 20 March 2008

Image:1mem.gif


PDB ID 1mem

Drag the structure with the mouse to rotate
, resolution 1.8Å
Sites:
Ligands: and
Activity: Cathepsin K, with EC number 3.4.22.38
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF CATHEPSIN K COMPLEXED WITH A POTENT VINYL SULFONE INHIBITOR


Disease

Known disease associated with this structure: Pycnodysostosis OMIM:[601105]

About this Structure

1MEM is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human cathepsin K complexed with a potent inhibitor., McGrath ME, Klaus JL, Barnes MG, Bromme D, Nat Struct Biol. 1997 Feb;4(2):105-9. PMID:9033587

Page seeded by OCA on Thu Mar 20 12:42:32 2008

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