1gj4
From Proteopedia
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{{STRUCTURE_1gj4| PDB=1gj4 | SCENE= }} | {{STRUCTURE_1gj4| PDB=1gj4 | SCENE= }} | ||
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===SELECTIVITY AT S1, H2O DISPLACEMENT, UPA, TPA, SER190/ALA190 PROTEASE, STRUCTURE-BASED DRUG DESIGN=== | ===SELECTIVITY AT S1, H2O DISPLACEMENT, UPA, TPA, SER190/ALA190 PROTEASE, STRUCTURE-BASED DRUG DESIGN=== | ||
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{{ABSTRACT_PUBMED_11731301}} | {{ABSTRACT_PUBMED_11731301}} | ||
Revision as of 09:20, 13 March 2013
Contents |
SELECTIVITY AT S1, H2O DISPLACEMENT, UPA, TPA, SER190/ALA190 PROTEASE, STRUCTURE-BASED DRUG DESIGN
Template:ABSTRACT PUBMED 11731301
About this Structure
1gj4 is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Katz BA, Sprengeler PA, Luong C, Verner E, Elrod K, Kirtley M, Janc J, Spencer JR, Breitenbucher JG, Hui H, McGee D, Allen D, Martelli A, Mackman RL. Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets. Chem Biol. 2001 Nov;8(11):1107-21. PMID:11731301
Categories: Homo sapiens | Thrombin | Allen, D. | Breitenbucher, J G. | Hui, H. | Katz, B A. | Luong, C. | Mackman, R L. | Martelli, A. | McGee, D. | Spencer, J R. | Sprengeler, P A. | Verner, E. | Blood clotting | Hydrolase | Hydrolase-hydrolase inhibitor complex | Oxyanion hole water | Shift of pka of his57 | Specificity | Structure-based drug design | Three-centered | Trypsin | Urokinase | Very short hydrogen bond | Zn+2-mediated inhibition
