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3qt2
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| - | [[ | + | ==Structure of a cytokine ligand-receptor complex== |
| + | <StructureSection load='3qt2' size='340' side='right' caption='[[3qt2]], [[Resolution|resolution]] 2.55Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3qt2]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QT2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QT2 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IL5R, IL5RA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), IL5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qt2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qt2 RCSB], [http://www.ebi.ac.uk/pdbsum/3qt2 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Interleukin-5 (IL-5) is the key mediator for the function of eosinophil granulocytes, whose deregulation is characteristic of hypereosinophilic diseases and presumably contributes to allergic asthma. IL-5 signaling involves two transmembrane receptors, IL-5Ralpha and the common beta chain, which upon formation of the ternary complex activate the JAK/STAT signaling cascade. To investigate the mechanism underlying ligand-receptor recognition, we determined the structure of IL-5 bound to the extracellular domain of IL-5Ralpha. IL-5 makes contact with all three fibronectin III-like domains of IL-5Ralpha, with the receptor architecture resembling a wrench. Mutagenesis data provide evidence that this wrench-like architecture is likely preformed. The structure demonstrates that for steric reasons, homodimeric IL-5 can bind only one receptor molecule, even though two equivalent receptor-binding sites exist. In regard to strong efforts being made to develop IL-5 antagonists for treating asthma and hypereosinophilic diseases, the advances in molecular understanding provided by this structure are of greatest value. | ||
| - | + | Structure analysis of the IL-5 ligand-receptor complex reveals a wrench-like architecture for IL-5Ralpha.,Patino E, Kotzsch A, Saremba S, Nickel J, Schmitz W, Sebald W, Mueller TD Structure. 2011 Dec 7;19(12):1864-75. PMID:22153509<ref>PMID:22153509</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | ||
| - | + | ||
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==See Also== | ==See Also== | ||
| + | *[[Interleukin|Interleukin]] | ||
*[[Interleukin receptor|Interleukin receptor]] | *[[Interleukin receptor|Interleukin receptor]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Kotzsch, A | + | [[Category: Kotzsch, A]] |
| - | [[Category: Mueller, T D | + | [[Category: Mueller, T D]] |
| - | [[Category: Nickel, J | + | [[Category: Nickel, J]] |
| - | [[Category: Patino, E | + | [[Category: Patino, E]] |
| - | [[Category: Saremba, S | + | [[Category: Saremba, S]] |
| - | [[Category: Schmitz, W | + | [[Category: Schmitz, W]] |
| - | [[Category: Sebald, W | + | [[Category: Sebald, W]] |
[[Category: Cytokine]] | [[Category: Cytokine]] | ||
[[Category: Cytokine type i receptor fold]] | [[Category: Cytokine type i receptor fold]] | ||
Revision as of 10:47, 9 December 2014
Structure of a cytokine ligand-receptor complex
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