2c3s

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[[Image:2c3s.png|left|200px]]
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==STRUCTURE OF SARS COV MAIN PROTEINASE AT 1.9 A (PH6.5)==
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<StructureSection load='2c3s' size='340' side='right' caption='[[2c3s]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2c3s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2bw6 2bw6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C3S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C3S FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1o5s|1o5s]], [[1p76|1p76]], [[1p9t|1p9t]], [[1pa5|1pa5]], [[1puk|1puk]], [[1q1x|1q1x]], [[1uj1|1uj1]], [[1uk2|1uk2]], [[1uk3|1uk3]], [[1uk4|1uk4]], [[1uw7|1uw7]], [[1wof|1wof]], [[2amd|2amd]], [[2amq|2amq]], [[2bx3|2bx3]], [[2bx4|2bx4]], [[2d2d|2d2d]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c3s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c3s RCSB], [http://www.ebi.ac.uk/pdbsum/2c3s PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c3/2c3s_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The 34 kDa main proteinase (Mpro) from the severe acute respiratory syndrome coronavirus (SARS-CoV) plays an important role in the virus life cycle through the specific processing of viral polyproteins. As such, SARS-CoV Mpro is a key target for the identification of specific inhibitors directed against the SARS virus. With a view to facilitating the development of such compounds, crystals were obtained of the enzyme at pH 6.5 in the orthorhombic space group P2(1)2(1)2 that diffract to a resolution of 1.9 A. These crystals contain one monomer per asymmetric unit and the biologically active dimer is generated via the crystallographic twofold axis. The conformation of the catalytic site indicates that the enzyme is active in the crystalline form and thus suitable for structure-based inhibition studies.
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{{STRUCTURE_2c3s| PDB=2c3s | SCENE= }}
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Structure of the SARS coronavirus main proteinase as an active C2 crystallographic dimer.,Xu T, Ooi A, Lee HC, Wilmouth R, Liu DX, Lescar J Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Nov 1;61(Pt, 11):964-6. Epub 2005 Oct 20. PMID:16511208<ref>PMID:16511208</ref>
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===STRUCTURE OF SARS COV MAIN PROTEINASE AT 1.9 A (PH6.5)===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_16511208}}
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==About this Structure==
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[[2c3s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2bw6 2bw6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C3S OCA].
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==See Also==
==See Also==
*[[SARS Coronavirus Main Proteinase|SARS Coronavirus Main Proteinase]]
*[[SARS Coronavirus Main Proteinase|SARS Coronavirus Main Proteinase]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:016511208</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Sars coronavirus]]
[[Category: Sars coronavirus]]
[[Category: Lee, H C.]]
[[Category: Lee, H C.]]

Revision as of 03:00, 29 September 2014

STRUCTURE OF SARS COV MAIN PROTEINASE AT 1.9 A (PH6.5)

2c3s, resolution 1.90Å

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