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1mpv

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[[Image:1mpv.gif|left|200px]]<br /><applet load="1mpv" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1mpv.gif|left|200px]]
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caption="1mpv" />
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'''Structure of bhpBR3, the BAFF-binding loop of BR3 embedded in a beta-hairpin peptide'''<br />
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{{Structure
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|PDB= 1mpv |SIZE=350|CAPTION= <scene name='initialview01'>1mpv</scene>
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|SITE=
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|LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene> and <scene name='pdbligand=NH2:AMINO GROUP'>NH2</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Structure of bhpBR3, the BAFF-binding loop of BR3 embedded in a beta-hairpin peptide'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1MPV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=ACE:'>ACE</scene> and <scene name='pdbligand=NH2:'>NH2</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MPV OCA].
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1MPV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MPV OCA].
==Reference==
==Reference==
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BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2., Kayagaki N, Yan M, Seshasayee D, Wang H, Lee W, French DM, Grewal IS, Cochran AG, Gordon NC, Yin J, Starovasnik MA, Dixit VM, Immunity. 2002 Oct;17(4):515-24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12387744 12387744]
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BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2., Kayagaki N, Yan M, Seshasayee D, Wang H, Lee W, French DM, Grewal IS, Cochran AG, Gordon NC, Yin J, Starovasnik MA, Dixit VM, Immunity. 2002 Oct;17(4):515-24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12387744 12387744]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Cochran, A G.]]
[[Category: Cochran, A G.]]
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[[Category: beta-hairpin]]
[[Category: beta-hairpin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:57:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:46:36 2008''

Revision as of 10:46, 20 March 2008

Image:1mpv.gif


PDB ID 1mpv

Drag the structure with the mouse to rotate
Ligands: and
Coordinates: save as pdb, mmCIF, xml



Structure of bhpBR3, the BAFF-binding loop of BR3 embedded in a beta-hairpin peptide


Overview

The TNF-like ligand BAFF/BLyS is a potent survival factor for B cells. It binds three receptors: TACI, BCMA, and BR3. We show that BR3 signaling promotes processing of the transcription factor NF-kappaB2/p100 to p52. NF-kappaB2/p100 cleavage was abrogated in B cells from A/WySnJ mice possessing a mutant BR3 gene, but not in TACI or BCMA null B cells. Furthermore, wild-type mice injected with BAFF-neutralizing BR3-Fc protein showed reduced basal NF-kappaB2 activation. BR3-Fc treatment of NZB/WF1 mice, which develop a fatal lupus-like syndrome, inhibited NF-kappaB2 processing and attenuated the disease process. Since inhibiting the BR3-BAFF interaction has therapeutic ramifications, the ligand binding interface of BR3 was investigated and found to reside within a 26 residue core domain. When stabilized within a structured beta-hairpin peptide, six of these residues were sufficient to confer binding to BAFF.

About this Structure

1MPV is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.

Reference

BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2., Kayagaki N, Yan M, Seshasayee D, Wang H, Lee W, French DM, Grewal IS, Cochran AG, Gordon NC, Yin J, Starovasnik MA, Dixit VM, Immunity. 2002 Oct;17(4):515-24. PMID:12387744

Page seeded by OCA on Thu Mar 20 12:46:36 2008

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