This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3b29

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:3b29.png|left|200px]]
 
- 
{{STRUCTURE_3b29| PDB=3b29 | SCENE= }}
{{STRUCTURE_3b29| PDB=3b29 | SCENE= }}
- 
===Human leukotriene C4 synthase in complex with dodecyl-beta-D-selenomaltoside===
===Human leukotriene C4 synthase in complex with dodecyl-beta-D-selenomaltoside===
 +
{{ABSTRACT_PUBMED_22139193}}
-
{{ABSTRACT_PUBMED_22139193}}
+
==Disease==
 +
[[http://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN]] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:[http://omim.org/entry/246530 246530]]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.
 +
 
 +
==Function==
 +
[[http://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN]] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.
==About this Structure==
==About this Structure==
Line 14: Line 16:
==Reference==
==Reference==
-
<ref group="xtra">PMID:022139193</ref><references group="xtra"/>
+
<ref group="xtra">PMID:022139193</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Ago, H.]]
[[Category: Ago, H.]]

Revision as of 16:59, 24 March 2013

Template:STRUCTURE 3b29

Contents

Human leukotriene C4 synthase in complex with dodecyl-beta-D-selenomaltoside

Template:ABSTRACT PUBMED 22139193

Disease

[LTC4S_HUMAN] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:246530]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.

Function

[LTC4S_HUMAN] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.

About this Structure

3b29 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Saino H, Ago H, Ukita Y, Miyano M. Seleno-detergent MAD phasing of leukotriene C4 synthase in complex with dodecyl-beta-D-selenomaltoside. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Dec 1;67(Pt 12):1666-73., Epub 2011 Nov 29. PMID:22139193 doi:10.1107/S1744309111042345

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3b29"
Personal tools