1muo

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[[Image:1muo.gif|left|200px]]<br /><applet load="1muo" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1muo.gif|left|200px]]
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caption="1muo, resolution 2.9&Aring;" />
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'''CRYSTAL STRUCTURE OF AURORA-2, AN ONCOGENIC SERINE-THREONINE KINASE'''<br />
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{{Structure
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|PDB= 1muo |SIZE=350|CAPTION= <scene name='initialview01'>1muo</scene>, resolution 2.9&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF AURORA-2, AN ONCOGENIC SERINE-THREONINE KINASE'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1MUO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ADN:'>ADN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MUO OCA].
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1MUO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MUO OCA].
==Reference==
==Reference==
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Crystal structure of aurora-2, an oncogenic serine/threonine kinase., Cheetham GM, Knegtel RM, Coll JT, Renwick SB, Swenson L, Weber P, Lippke JA, Austen DA, J Biol Chem. 2002 Nov 8;277(45):42419-22. Epub 2002 Sep 16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12237287 12237287]
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Crystal structure of aurora-2, an oncogenic serine/threonine kinase., Cheetham GM, Knegtel RM, Coll JT, Renwick SB, Swenson L, Weber P, Lippke JA, Austen DA, J Biol Chem. 2002 Nov 8;277(45):42419-22. Epub 2002 Sep 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12237287 12237287]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: transferase]]
[[Category: transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:59:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:48:24 2008''

Revision as of 10:48, 20 March 2008

Image:1muo.gif


PDB ID 1muo

Drag the structure with the mouse to rotate
, resolution 2.9Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF AURORA-2, AN ONCOGENIC SERINE-THREONINE KINASE


Contents

Overview

Aurora-2 is a key member of a closely related subgroup of serine/threonine kinases that plays important roles in the completion of essential mitotic events. Aurora-2 is oncogenic and amplified in various human cancers and could be an important therapeutic target for inhibitory molecules that would disrupt the cell cycle and block proliferation. We report the first crystal structure of Aurora-2 kinase in complex with adenosine. Analysis of residues in the active site suggests differences with structurally and biologically related protein kinases. The activation loop, which contains residues specific to the Aurora family of kinases, has a unique conformation. These results provide valuable insight into the design of selective and highly potent ATP-competitive inhibitors of the Aurora kinases.

Disease

Known diseases associated with this structure: Colon cancer, susceptibility to OMIM:[603072]

About this Structure

1MUO is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of aurora-2, an oncogenic serine/threonine kinase., Cheetham GM, Knegtel RM, Coll JT, Renwick SB, Swenson L, Weber P, Lippke JA, Austen DA, J Biol Chem. 2002 Nov 8;277(45):42419-22. Epub 2002 Sep 16. PMID:12237287

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