1muq
From Proteopedia
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| - | [[Image:1muq.gif|left|200px]] | + | [[Image:1muq.gif|left|200px]] |
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| - | '''X-ray Crystal Structure of Rattlesnake Venom Complexed With Thiodigalactoside''' | + | {{Structure |
| + | |PDB= 1muq |SIZE=350|CAPTION= <scene name='initialview01'>1muq</scene>, resolution 2.30Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene> and <scene name='pdbligand=TDG:THIODIGALACTOSIDE'>TDG</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''X-ray Crystal Structure of Rattlesnake Venom Complexed With Thiodigalactoside''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1MUQ is a [ | + | 1MUQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Crotalus_atrox Crotalus atrox]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MUQ OCA]. |
==Reference== | ==Reference== | ||
| - | X-ray crystal structure of a galactose-specific C-type lectin possessing a novel decameric quaternary structure., Walker JR, Nagar B, Young NM, Hirama T, Rini JM, Biochemistry. 2004 Apr 6;43(13):3783-92. PMID:[http:// | + | X-ray crystal structure of a galactose-specific C-type lectin possessing a novel decameric quaternary structure., Walker JR, Nagar B, Young NM, Hirama T, Rini JM, Biochemistry. 2004 Apr 6;43(13):3783-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15049685 15049685] |
[[Category: Crotalus atrox]] | [[Category: Crotalus atrox]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: protein-carbohydrate complex]] | [[Category: protein-carbohydrate complex]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:48:24 2008'' |
Revision as of 10:48, 20 March 2008
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| , resolution 2.30Å | |||||||
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| Ligands: | , , and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
X-ray Crystal Structure of Rattlesnake Venom Complexed With Thiodigalactoside
Overview
Rattlesnake venom lectin (RSL) from the western diamondback rattlesnake (Crotalus atrox) is an oligomeric galactose-specific C-type lectin. The X-ray crystal structure of RSL, in complex with lactose and thiodigalactoside, at 2.2 and 2.3 A resolution, respectively, reveals a decameric protein composed of two 5-fold symmetric pentamers arranged in a staggered, back-to-back orientation. Each monomer corresponds to a single canonical C-type lectin carbohydrate recognition domain devoid of accessory domains and is disulfide-bonded to a monomer in the other pentamer. The structure is the first example of that of a carbohydrate complex of a vertebrate galactose-specific C-type lectin. The 10 carbohydrate-binding sites, located on the rim of the decamer, suggest a role for multivalent interactions and a mechanism for RSL's ability to promote receptor cross-linking and cell aggregation.
About this Structure
1MUQ is a Single protein structure of sequence from Crotalus atrox. Full crystallographic information is available from OCA.
Reference
X-ray crystal structure of a galactose-specific C-type lectin possessing a novel decameric quaternary structure., Walker JR, Nagar B, Young NM, Hirama T, Rini JM, Biochemistry. 2004 Apr 6;43(13):3783-92. PMID:15049685
Page seeded by OCA on Thu Mar 20 12:48:24 2008
Categories: Crotalus atrox | Single protein | Hirama, T. | Nagar, B. | Rini, J M. | Walker, J R. | Young, N M. | CA | GAL | NA | TDG | C-type lectin | Calcium binding | Decamer | Protein-carbohydrate complex
