2wxz

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[[Image:2wxz.png|left|200px]]
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==CRYSTAL STRUCTURE OF RAT ANGIOTENSINOGEN IN C2 SPACE GROUP==
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<StructureSection load='2wxz' size='340' side='right' caption='[[2wxz]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2wxz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WXZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WXZ FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2x0b|2x0b]], [[2wxy|2wxy]], [[2wy1|2wy1]], [[2wy0|2wy0]], [[2wxw|2wxw]], [[2wxx|2wxx]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wxz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wxz RCSB], [http://www.ebi.ac.uk/pdbsum/2wxz PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Blood pressure is critically controlled by angiotensins, which are vasopressor peptides specifically released by the enzyme renin from the tail of angiotensinogen-a non-inhibitory member of the serpin family of protease inhibitors. Although angiotensinogen has long been regarded as a passive substrate, the crystal structures solved here to 2.1 A resolution show that the angiotensin cleavage site is inaccessibly buried in its amino-terminal tail. The conformational rearrangement that makes this site accessible for proteolysis is revealed in our 4.4 A structure of the complex of human angiotensinogen with renin. The co-ordinated changes involved are seen to be critically linked by a conserved but labile disulphide bridge. Here we show that the reduced unbridged form of angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized sulphydryl-bridged form, which preferentially interacts with receptor-bound renin. We propose that this redox-responsive transition of angiotensinogen to a form that will more effectively release angiotensin at a cellular level contributes to the modulation of blood pressure. Specifically, we demonstrate the oxidative switch of angiotensinogen to its more active sulphydryl-bridged form in the maternal circulation in pre-eclampsia-the hypertensive crisis of pregnancy that threatens the health and survival of both mother and child.
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{{STRUCTURE_2wxz| PDB=2wxz | SCENE= }}
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A redox switch in angiotensinogen modulates angiotensin release.,Zhou A, Carrell RW, Murphy MP, Wei Z, Yan Y, Stanley PL, Stein PE, Pipkin FB, Read RJ Nature. 2010 Oct 6. PMID:20927107<ref>PMID:20927107</ref>
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===CRYSTAL STRUCTURE OF RAT ANGIOTENSINOGEN IN C2 SPACE GROUP===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_20927107}}
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==About this Structure==
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[[2wxz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WXZ OCA].
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==See Also==
==See Also==
*[[Hormone|Hormone]]
*[[Hormone|Hormone]]
*[[Serpin|Serpin]]
*[[Serpin|Serpin]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:020927107</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Carrell, R W.]]
[[Category: Carrell, R W.]]

Revision as of 01:00, 2 October 2014

CRYSTAL STRUCTURE OF RAT ANGIOTENSINOGEN IN C2 SPACE GROUP

2wxz, resolution 2.80Å

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