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1h5o

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[[Image:1h5o.png|left|200px]]
 
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{{STRUCTURE_1h5o| PDB=1h5o | SCENE= }}
{{STRUCTURE_1h5o| PDB=1h5o | SCENE= }}
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===Solution structure of Crotamine, a neurotoxin from Crotalus durissus terrificus===
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{{ABSTRACT_PUBMED_12709056}}
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===SOLUTION STRUCTURE OF CROTAMINE, A NEUROTOXIN FROM CROTALUS DURISSUS TERRIFICUS===
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==Function==
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[[http://www.uniprot.org/uniprot/MYXC_CRODU MYXC_CRODU]] This toxin specifically modifies voltage-gated sodium channels (Nav), it exhibits analgesic activity and causes severe muscle necrosis by a non-enzymatic mechanism. Moreover, it actively interacts with lipid membranes.<ref>PMID:1176086</ref> <ref>PMID:9839677</ref>
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{{ABSTRACT_PUBMED_12709056}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:012709056</ref><references group="xtra"/>
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<ref group="xtra">PMID:012709056</ref><references group="xtra"/><references/>
[[Category: Crotalus durissus terrificus]]
[[Category: Crotalus durissus terrificus]]
[[Category: Chiara, C De.]]
[[Category: Chiara, C De.]]
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[[Category: Nicastro, G.]]
[[Category: Nicastro, G.]]
[[Category: Spisni, A.]]
[[Category: Spisni, A.]]
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[[Category: Neurotoxin]]
 
[[Category: Sodium channel affecting toxin]]
[[Category: Sodium channel affecting toxin]]
[[Category: Toxin]]
[[Category: Toxin]]
[[Category: Venom]]
[[Category: Venom]]

Revision as of 11:24, 24 July 2013

Template:STRUCTURE 1h5o

Contents

Solution structure of Crotamine, a neurotoxin from Crotalus durissus terrificus

Template:ABSTRACT PUBMED 12709056

Function

[MYXC_CRODU] This toxin specifically modifies voltage-gated sodium channels (Nav), it exhibits analgesic activity and causes severe muscle necrosis by a non-enzymatic mechanism. Moreover, it actively interacts with lipid membranes.[1] [2]

About this Structure

1h5o is a 1 chain structure with sequence from Crotalus durissus terrificus. Full experimental information is available from OCA.

See Also

Reference

  • Nicastro G, Franzoni L, de Chiara C, Mancin AC, Giglio JR, Spisni A. Solution structure of crotamine, a Na+ channel affecting toxin from Crotalus durissus terrificus venom. Eur J Biochem. 2003 May;270(9):1969-79. PMID:12709056
  1. ↑ Laure CJ. [The primary structure of crotamine (author's transl)]. Hoppe Seylers Z Physiol Chem. 1975 Feb;356(2):213-5. PMID:1176086
  2. ↑ Mancin AC, Soares AM, Andriao-Escarso SH, Faca VM, Greene LJ, Zuccolotto S, Pela IR, Giglio JR. The analgesic activity of crotamine, a neurotoxin from Crotalus durissus terrificus (South American rattlesnake) venom: a biochemical and pharmacological study. Toxicon. 1998 Dec;36(12):1927-37. PMID:9839677

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