3ddf
From Proteopedia
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{{STRUCTURE_3ddf| PDB=3ddf | SCENE= }} | {{STRUCTURE_3ddf| PDB=3ddf | SCENE= }} | ||
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===GOLGI MANNOSIDASE II complex with (3R,4R,5R)-3,4-Dihydroxy-5-({[(1R)-2-hydroxy-1 phenylethyl]amino}methyl) pyrrolidin-2-one=== | ===GOLGI MANNOSIDASE II complex with (3R,4R,5R)-3,4-Dihydroxy-5-({[(1R)-2-hydroxy-1 phenylethyl]amino}methyl) pyrrolidin-2-one=== | ||
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{{ABSTRACT_PUBMED_18599296}} | {{ABSTRACT_PUBMED_18599296}} | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/MAN2_DROME MAN2_DROME]] Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway (By similarity). | ||
==About this Structure== | ==About this Structure== | ||
[[3ddf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DDF OCA]. | [[3ddf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DDF OCA]. | ||
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| - | ==See Also== | ||
| - | *[[Mannosidase|Mannosidase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:018599296</ref><references group="xtra"/> | + | <ref group="xtra">PMID:018599296</ref><references group="xtra"/><references/> |
[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
[[Category: Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase]] | [[Category: Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase]] | ||
Revision as of 10:22, 3 July 2013
Contents |
GOLGI MANNOSIDASE II complex with (3R,4R,5R)-3,4-Dihydroxy-5-({[(1R)-2-hydroxy-1 phenylethyl]amino}methyl) pyrrolidin-2-one
Template:ABSTRACT PUBMED 18599296
Function
[MAN2_DROME] Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway (By similarity).
About this Structure
3ddf is a 1 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.
Reference
- Fiaux H, Kuntz DA, Hoffman D, Janzer RC, Gerber-Lemaire S, Rose DR, Juillerat-Jeanneret L. Functionalized pyrrolidine inhibitors of human type II alpha-mannosidases as anti-cancer agents: optimizing the fit to the active site. Bioorg Med Chem. 2008 Aug 1;16(15):7337-46. Epub 2008 Jun 14. PMID:18599296 doi:10.1016/j.bmc.2008.06.021
