3be8

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[[Image:3be8.png|left|200px]]
 
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{{STRUCTURE_3be8| PDB=3be8 | SCENE= }}
{{STRUCTURE_3be8| PDB=3be8 | SCENE= }}
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===Crystal structure of the synaptic protein neuroligin 4===
===Crystal structure of the synaptic protein neuroligin 4===
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{{ABSTRACT_PUBMED_18093521}}
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{{ABSTRACT_PUBMED_18093521}}
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==Disease==
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[[http://www.uniprot.org/uniprot/NLGNX_HUMAN NLGNX_HUMAN]] Defects in NLGN4X may be the cause of susceptibility to autism X-linked type 2 (AUTSX2) [MIM:[http://omim.org/entry/300495 300495]]. AUTSX2 is a pervasive developmental disorder (PDD), prototypically characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age.<ref>PMID:12669065</ref> Defects in NLGN4X may be the cause of susceptibility to X-linked Asperger syndrome 2 (ASPGX2) [MIM:[http://omim.org/entry/300497 300497]]. ASPGX2 is considered to be a form of childhood autism.
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==Function==
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[[http://www.uniprot.org/uniprot/NLGNX_HUMAN NLGNX_HUMAN]] Putative neuronal cell surface protein involved in cell-cell-interactions.
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:018093521</ref><references group="xtra"/>
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<ref group="xtra">PMID:018093521</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bourne, Y.]]
[[Category: Bourne, Y.]]

Revision as of 22:43, 24 March 2013

Template:STRUCTURE 3be8

Contents

Crystal structure of the synaptic protein neuroligin 4

Template:ABSTRACT PUBMED 18093521

Disease

[NLGNX_HUMAN] Defects in NLGN4X may be the cause of susceptibility to autism X-linked type 2 (AUTSX2) [MIM:300495]. AUTSX2 is a pervasive developmental disorder (PDD), prototypically characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age.[1] Defects in NLGN4X may be the cause of susceptibility to X-linked Asperger syndrome 2 (ASPGX2) [MIM:300497]. ASPGX2 is considered to be a form of childhood autism.

Function

[NLGNX_HUMAN] Putative neuronal cell surface protein involved in cell-cell-interactions.

About this Structure

3be8 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Fabrichny IP, Leone P, Sulzenbacher G, Comoletti D, Miller MT, Taylor P, Bourne Y, Marchot P. Structural analysis of the synaptic protein neuroligin and its beta-neurexin complex: determinants for folding and cell adhesion. Neuron. 2007 Dec 20;56(6):979-91. PMID:18093521 doi:10.1016/j.neuron.2007.11.013
  1. ↑ Jamain S, Quach H, Betancur C, Rastam M, Colineaux C, Gillberg IC, Soderstrom H, Giros B, Leboyer M, Gillberg C, Bourgeron T. Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism. Nat Genet. 2003 May;34(1):27-9. PMID:12669065 doi:10.1038/ng1136

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