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1udz

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[[Image:1udz.png|left|200px]]
 
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{{STRUCTURE_1udz| PDB=1udz | SCENE= }}
{{STRUCTURE_1udz| PDB=1udz | SCENE= }}
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===Isoleucyl-tRNA synthetase editing domain===
===Isoleucyl-tRNA synthetase editing domain===
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{{ABSTRACT_PUBMED_14672940}}
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{{ABSTRACT_PUBMED_14672940}}
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==Function==
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[[http://www.uniprot.org/uniprot/SYI_THET8 SYI_THET8]] Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity).[HAMAP-Rule:MF_02003]
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:014672940</ref><references group="xtra"/>
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<ref group="xtra">PMID:014672940</ref><references group="xtra"/><references/>
[[Category: Isoleucine--tRNA ligase]]
[[Category: Isoleucine--tRNA ligase]]
[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]

Revision as of 02:48, 20 September 2013

Template:STRUCTURE 1udz

Contents

Isoleucyl-tRNA synthetase editing domain

Template:ABSTRACT PUBMED 14672940

Function

[SYI_THET8] Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity).[HAMAP-Rule:MF_02003]

About this Structure

1udz is a 2 chain structure with sequence from Thermus thermophilus. Full crystallographic information is available from OCA.

See Also

Reference

  • Fukunaga R, Fukai S, Ishitani R, Nureki O, Yokoyama S. Crystal structures of the CP1 domain from Thermus thermophilus isoleucyl-tRNA synthetase and its complex with L-valine. J Biol Chem. 2004 Feb 27;279(9):8396-402. Epub 2003 Dec 12. PMID:14672940 doi:10.1074/jbc.M312830200

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OCA

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