2r9h
From Proteopedia
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{{STRUCTURE_2r9h| PDB=2r9h | SCENE= }} | {{STRUCTURE_2r9h| PDB=2r9h | SCENE= }} | ||
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===Crystal Structure of Q207C Mutant of CLC-ec1 in complex with Fab=== | ===Crystal Structure of Q207C Mutant of CLC-ec1 in complex with Fab=== | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/CLCA_ECOLI CLCA_ECOLI]] Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response.<ref>PMID:12384697</ref> <ref>PMID:14985752</ref> <ref>PMID:16341087</ref> <ref>PMID:16905147</ref> <ref>PMID:18678918</ref> | ||
==About this Structure== | ==About this Structure== | ||
| - | [[2r9h]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9H OCA]. | + | [[2r9h]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9H OCA]. |
==See Also== | ==See Also== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:018093952</ref><references group="xtra"/> | + | <ref group="xtra">PMID:018093952</ref><references group="xtra"/><references/> |
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| + | [[Category: Mus musculus]] | ||
[[Category: Miller, C.]] | [[Category: Miller, C.]] | ||
[[Category: Nguitragool, W.]] | [[Category: Nguitragool, W.]] | ||
Revision as of 05:57, 2 October 2013
Contents |
Crystal Structure of Q207C Mutant of CLC-ec1 in complex with Fab
Function
[CLCA_ECOLI] Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response.[1] [2] [3] [4] [5]
About this Structure
2r9h is a 6 chain structure with sequence from Escherichia coli and Mus musculus. Full crystallographic information is available from OCA.
See Also
Reference
- Nguitragool W, Miller C. CLC Cl /H+ transporters constrained by covalent cross-linking. Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20659-65. Epub 2007 Dec 18. PMID:18093952 doi:10.1073/pnas.0708639104
- ↑ Iyer R, Iverson TM, Accardi A, Miller C. A biological role for prokaryotic ClC chloride channels. Nature. 2002 Oct 17;419(6908):715-8. PMID:12384697 doi:10.1038/nature01000
- ↑ Accardi A, Miller C. Secondary active transport mediated by a prokaryotic homologue of ClC Cl- channels. Nature. 2004 Feb 26;427(6977):803-7. PMID:14985752 doi:10.1038/nature02314
- ↑ Lobet S, Dutzler R. Ion-binding properties of the ClC chloride selectivity filter. EMBO J. 2006 Jan 11;25(1):24-33. Epub 2005 Dec 8. PMID:16341087
- ↑ Nguitragool W, Miller C. Uncoupling of a CLC Cl-/H+ exchange transporter by polyatomic anions. J Mol Biol. 2006 Sep 29;362(4):682-90. Epub 2006 Aug 14. PMID:16905147 doi:10.1016/j.jmb.2006.07.006
- ↑ Jayaram H, Accardi A, Wu F, Williams C, Miller C. Ion permeation through a Cl--selective channel designed from a CLC Cl-/H+ exchanger. Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11194-9. Epub 2008 Aug 4. PMID:18678918
