1xyk

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[[Image:1xyk.png|left|200px]]
 
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{{STRUCTURE_1xyk| PDB=1xyk | SCENE= }}
{{STRUCTURE_1xyk| PDB=1xyk | SCENE= }}
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===NMR Structure of the canine prion protein===
===NMR Structure of the canine prion protein===
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{{ABSTRACT_PUBMED_15647367}}
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{{ABSTRACT_PUBMED_15647367}}
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==Disease==
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[[http://www.uniprot.org/uniprot/PRIO_CANFA PRIO_CANFA]] Note=PrP is found in high quantity in the brain of humans and animals infected with the degenerative neurological diseases kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
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==Function==
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[[http://www.uniprot.org/uniprot/PRIO_CANFA PRIO_CANFA]] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:015647367</ref><references group="xtra"/>
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<ref group="xtra">PMID:015647367</ref><references group="xtra"/><references/>
[[Category: Canis lupus familiaris]]
[[Category: Canis lupus familiaris]]
[[Category: Esteve-Moya, V.]]
[[Category: Esteve-Moya, V.]]

Revision as of 00:04, 25 March 2013

Template:STRUCTURE 1xyk

Contents

NMR Structure of the canine prion protein

Template:ABSTRACT PUBMED 15647367

Disease

[PRIO_CANFA] Note=PrP is found in high quantity in the brain of humans and animals infected with the degenerative neurological diseases kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.

Function

[PRIO_CANFA] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).

About this Structure

1xyk is a 1 chain structure with sequence from Canis lupus familiaris. Full experimental information is available from OCA.

See Also

Reference

  • Lysek DA, Schorn C, Nivon LG, Esteve-Moya V, Christen B, Calzolai L, von Schroetter C, Fiorito F, Herrmann T, Guntert P, Wuthrich K. Prion protein NMR structures of cats, dogs, pigs, and sheep. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):640-5. Epub 2005 Jan 12. PMID:15647367

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OCA

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