1na3

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[[Image:1na3.jpg|left|200px]]<br /><applet load="1na3" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1na3.jpg|left|200px]]
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caption="1na3, resolution 1.55&Aring;" />
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'''Design of Stable alpha-Helical Arrays from an Idealized TPR Motif'''<br />
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{{Structure
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|PDB= 1na3 |SIZE=350|CAPTION= <scene name='initialview01'>1na3</scene>, resolution 1.55&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene> and <scene name='pdbligand=IPT:ISOPROPYL-1-BETA-D-THIOGALACTOSIDE'>IPT</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Design of Stable alpha-Helical Arrays from an Idealized TPR Motif'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1NA3 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=TRS:'>TRS</scene> and <scene name='pdbligand=IPT:'>IPT</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NA3 OCA].
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1NA3 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NA3 OCA].
==Reference==
==Reference==
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Design of stable alpha-helical arrays from an idealized TPR motif., Main ER, Xiong Y, Cocco MJ, D'Andrea L, Regan L, Structure. 2003 May;11(5):497-508. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12737816 12737816]
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Design of stable alpha-helical arrays from an idealized TPR motif., Main ER, Xiong Y, Cocco MJ, D'Andrea L, Regan L, Structure. 2003 May;11(5):497-508. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12737816 12737816]
[[Category: ]]
[[Category: ]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: tpr]]
[[Category: tpr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:03:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:54:13 2008''

Revision as of 10:54, 20 March 2008

Image:1na3.jpg


PDB ID 1na3

Drag the structure with the mouse to rotate
, resolution 1.55Å
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



Design of Stable alpha-Helical Arrays from an Idealized TPR Motif


Overview

The tetratricopeptide repeat (TPR) is a 34-amino acid alpha-helical motif that occurs in over 300 different proteins. In the different proteins, three to sixteen or more TPR motifs occur in tandem arrays and function to mediate protein-protein interactions. The binding specificity of each TPR protein is different, although the underlying structural motif is the same. Here we describe a statistical approach to the design of an idealized TPR motif. We present the high-resolution X-ray crystal structures (to 1.55 and 1.6 A) of designed TPR proteins and describe their solution properties and stability. A detailed analysis of these structures provides an understanding of the TPR motif, how it is repeated to give helical arrays with different superhelical twists, and how a very stable framework may be constructed for future functional designs.

About this Structure

1NA3 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Design of stable alpha-helical arrays from an idealized TPR motif., Main ER, Xiong Y, Cocco MJ, D'Andrea L, Regan L, Structure. 2003 May;11(5):497-508. PMID:12737816 [[Category: ]]

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