2wrm
From Proteopedia
(Difference between revisions)
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| - | + | ==IDENTIFICATION OF NOVEL ALLOSTERIC INHIBITORS OF HEPATITIS C VIRUS NS5B POLYMERASE THUMB DOMAIN (SITE II) BY STRUCTURE-BASED DESIGN== | |
| - | + | <StructureSection load='2wrm' size='340' side='right' caption='[[2wrm]], [[Resolution|resolution]] 1.95Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2wrm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WRM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WRM FirstGlance]. <br> | |
| - | + | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QQ3:(3R)-3-(4-METHYL-1,3-DIOXO-1,3-DIHYDRO-2H-PYRROLO[3,4-C]QUINOLIN-2-YL)HEXANOIC+ACID'>QQ3</scene><br> | |
| - | + | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1nhu|1nhu]], [[2i1r|2i1r]], [[2wcx|2wcx]], [[1jxp|1jxp]], [[1gx6|1gx6]], [[2jc1|2jc1]], [[8ohm|8ohm]], [[1c2p|1c2p]], [[1a1q|1a1q]], [[1bt7|1bt7]], [[1cu1|1cu1]], [[1ns3|1ns3]], [[2jc0|2jc0]], [[2ax1|2ax1]], [[2who|2who]], [[1nhv|1nhv]], [[1csj|1csj]], [[1gx5|1gx5]], [[2brk|2brk]], [[2brl|2brl]], [[2awz|2awz]], [[2ax0|2ax0]], [[1quv|1quv]], [[1os5|1os5]]</td></tr> | |
| - | + | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr> | |
| - | == | + | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wrm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wrm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wrm RCSB], [http://www.ebi.ac.uk/pdbsum/2wrm PDBsum]</span></td></tr> |
| - | [[2wrm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WRM OCA]. | + | <table> |
==See Also== | ==See Also== | ||
*[[RNA polymerase|RNA polymerase]] | *[[RNA polymerase|RNA polymerase]] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Hepatitis c virus]] | [[Category: Hepatitis c virus]] | ||
[[Category: RNA-directed RNA polymerase]] | [[Category: RNA-directed RNA polymerase]] | ||
Revision as of 01:03, 2 October 2014
IDENTIFICATION OF NOVEL ALLOSTERIC INHIBITORS OF HEPATITIS C VIRUS NS5B POLYMERASE THUMB DOMAIN (SITE II) BY STRUCTURE-BASED DESIGN
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