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1b07

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[[Image:1b07.png|left|200px]]
 
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{{STRUCTURE_1b07| PDB=1b07 | SCENE= }}
{{STRUCTURE_1b07| PDB=1b07 | SCENE= }}
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===CRK SH3 DOMAIN COMPLEXED WITH PEPTOID INHIBITOR===
===CRK SH3 DOMAIN COMPLEXED WITH PEPTOID INHIBITOR===
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{{ABSTRACT_PUBMED_9851931}}
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{{ABSTRACT_PUBMED_9851931}}
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==Function==
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[[http://www.uniprot.org/uniprot/CRK_MOUSE CRK_MOUSE]] The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
==About this Structure==
==About this Structure==
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[[1b07]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B07 OCA].
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[[1b07]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B07 OCA].
==See Also==
==See Also==
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==Reference==
==Reference==
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<ref group="xtra">PMID:009851931</ref><references group="xtra"/>
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<ref group="xtra">PMID:009851931</ref><references group="xtra"/><references/>
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[[Category: Mus musculus]]
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[[Category: Lk3 transgenic mice]]
[[Category: Cohen, F E.]]
[[Category: Cohen, F E.]]
[[Category: Lim, W A.]]
[[Category: Lim, W A.]]

Revision as of 08:53, 25 December 2013

Template:STRUCTURE 1b07

Contents

CRK SH3 DOMAIN COMPLEXED WITH PEPTOID INHIBITOR

Template:ABSTRACT PUBMED 9851931

Function

[CRK_MOUSE] The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.

About this Structure

1b07 is a 2 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA.

See Also

Reference

  • Nguyen JT, Turck CW, Cohen FE, Zuckermann RN, Lim WA. Exploiting the basis of proline recognition by SH3 and WW domains: design of N-substituted inhibitors. Science. 1998 Dec 11;282(5396):2088-92. PMID:9851931

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