3rbe

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[[Image:3rbe.png|left|200px]]
 
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{{STRUCTURE_3rbe| PDB=3rbe | SCENE= }}
{{STRUCTURE_3rbe| PDB=3rbe | SCENE= }}
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===Dpo4 extension ternary complex with 3'-terminal primer t base opposite the 3-methylcytosine (m3c) lesion===
===Dpo4 extension ternary complex with 3'-terminal primer t base opposite the 3-methylcytosine (m3c) lesion===
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{{ABSTRACT_PUBMED_21645853}}
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==Function==
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[[http://www.uniprot.org/uniprot/DPO4_SULSO DPO4_SULSO]] Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. It is involved in translesional synthesis.[HAMAP-Rule:MF_01113]
==About this Structure==
==About this Structure==
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[[3rbe]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RBE OCA].
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[[3rbe]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus_p2 Sulfolobus solfataricus p2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RBE OCA].
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==See Also==
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==Reference==
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*[[DNA polymerase|DNA polymerase]]
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<ref group="xtra">PMID:021645853</ref><references group="xtra"/><references/>
[[Category: DNA-directed DNA polymerase]]
[[Category: DNA-directed DNA polymerase]]
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[[Category: Sulfolobus solfataricus]]
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[[Category: Sulfolobus solfataricus p2]]
[[Category: Patel, D J.]]
[[Category: Patel, D J.]]
[[Category: Rechkoblit, O.]]
[[Category: Rechkoblit, O.]]

Revision as of 10:09, 19 June 2013

Template:STRUCTURE 3rbe

Contents

Dpo4 extension ternary complex with 3'-terminal primer t base opposite the 3-methylcytosine (m3c) lesion

Template:ABSTRACT PUBMED 21645853

Function

[DPO4_SULSO] Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. It is involved in translesional synthesis.[HAMAP-Rule:MF_01113]

About this Structure

3rbe is a 6 chain structure with sequence from Sulfolobus solfataricus p2. Full crystallographic information is available from OCA.

Reference

  • Rechkoblit O, Delaney JC, Essigmann JM, Patel DJ. Implications for damage recognition during Dpo4-mediated mutagenic bypass of m1G and m3C lesions. Structure. 2011 Jun 8;19(6):821-32. doi: 10.1016/j.str.2011.03.020. PMID:21645853 doi:10.1016/j.str.2011.03.020

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