3a7c

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[[Image:3a7c.png|left|200px]]
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==Crystal structure of TLR2-PE-DTPA complex==
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<StructureSection load='3a7c' size='340' side='right' caption='[[3a7c]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3a7c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Eptatretus_burgeri Eptatretus burgeri]. The November 2011 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Toll-like Receptors'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2011_11 10.2210/rcsb_pdb/mom_2011_11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A7C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3A7C FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LU:LUTETIUM+(III)+ION'>LU</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PDK:(10S,13R)-3-{2-[{2-[BIS(CARBOXYMETHYL)AMINO]ETHYL}(CARBOXYMETHYL)AMINO]ETHYL}-10-HYDROXY-5,16-DIOXO-13-(TETRADECANOYLOXY)-9,11,15-TRIOXA-3,6-DIAZA-10-PHOSPHANONACOSAN-1-OIC+ACID+10-OXIDE'>PDK</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3a79|3a79]], [[3a7b|3a7b]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tlr2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7764 Eptatretus burgeri])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3a7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a7c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3a7c RCSB], [http://www.ebi.ac.uk/pdbsum/3a7c PDBsum]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/TLR2_MOUSE TLR2_MOUSE]] Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins (By similarity).<ref>PMID:19931471</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a7/3a7c_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Toll-like receptor 2 (TLR2) initiates potent immune responses by recognizing diacylated and triacylated lipopeptides. Its ligand specificity is controlled by whether it heterodimerizes with TLR1 or TLR6. We have determined the crystal structures of TLR2-TLR6-diacylated lipopeptide, TLR2-lipoteichoic acid, and TLR2-PE-DTPA complexes. PE-DTPA, 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepenta acetic acid, is a synthetic phospholipid derivative. Two major factors contribute to the ligand specificity of TLR2-TLR1 or TLR2-TLR6 heterodimers. First, the lipid channel of TLR6 is blocked by two phenylalanines. Simultaneous mutation of these phenylalanines made TLR2-TLR6 fully responsive not only to diacylated but also to triacylated lipopeptides. Second, the hydrophobic dimerization interface of TLR2-TLR6 is increased by 80%, which compensates for the lack of amide lipid interaction between the lipopeptide and TLR2-TLR6. The structures of the TLR2-lipoteichoic acid and the TLR2-PE-DTPA complexes demonstrate that a precise interaction pattern of the head group is essential for a robust immune response by TLR2 heterodimers.
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{{STRUCTURE_3a7c| PDB=3a7c | SCENE= }}
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Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer.,Kang JY, Nan X, Jin MS, Youn SJ, Ryu YH, Mah S, Han SH, Lee H, Paik SG, Lee JO Immunity. 2009 Dec 18;31(6):873-84. PMID:19931471<ref>PMID:19931471</ref>
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===Crystal structure of TLR2-PE-DTPA complex===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_19931471}}
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==About this Structure==
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[[3a7c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Eptatretus_burgeri Eptatretus burgeri]. The November 2011 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Toll-like Receptors'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2011_11 10.2210/rcsb_pdb/mom_2011_11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A7C OCA].
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==See Also==
==See Also==
*[[Toll-like Receptors|Toll-like Receptors]]
*[[Toll-like Receptors|Toll-like Receptors]]
*[[Variable lymphocyte receptor|Variable lymphocyte receptor]]
*[[Variable lymphocyte receptor|Variable lymphocyte receptor]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019931471</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Eptatretus burgeri]]
[[Category: Eptatretus burgeri]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Toll-like Receptors]]
[[Category: Toll-like Receptors]]
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[[Category: Jin, M S.]]
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[[Category: Jin, M S]]
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[[Category: Kang, J Y.]]
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[[Category: Kang, J Y]]
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[[Category: Lee, J O.]]
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[[Category: Lee, J O]]
[[Category: Cell membrane]]
[[Category: Cell membrane]]
[[Category: Cytoplasmic vesicle]]
[[Category: Cytoplasmic vesicle]]

Revision as of 14:53, 25 December 2014

Crystal structure of TLR2-PE-DTPA complex

3a7c, resolution 2.40Å

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