1ng1
From Proteopedia
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| - | [[Image:1ng1.jpg|left|200px]] | + | [[Image:1ng1.jpg|left|200px]] |
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| - | '''N AND GTPASE DOMAINS OF THE SIGNAL SEQUENCE RECOGNITION PROTEIN FFH FROM THERMUS AQUATICUS''' | + | {{Structure |
| + | |PDB= 1ng1 |SIZE=350|CAPTION= <scene name='initialview01'>1ng1</scene>, resolution 2.03Å | ||
| + | |SITE= <scene name='pdbsite=I:Gtpase+Binding+Site+Motif'>I</scene>, <scene name='pdbsite=II:Gtpase+Binding+Site+Motif'>II</scene>, <scene name='pdbsite=III:Gtpase+Binding+Site+Motif'>III</scene> and <scene name='pdbsite=IV:Gtpase+Binding+Site+Motif'>IV</scene> | ||
| + | |LIGAND= <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=GDP:GUANOSINE-5'-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene> and <scene name='pdbligand=ACY:ACETIC ACID'>ACY</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= FFH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=271 Thermus aquaticus]) | ||
| + | }} | ||
| + | |||
| + | '''N AND GTPASE DOMAINS OF THE SIGNAL SEQUENCE RECOGNITION PROTEIN FFH FROM THERMUS AQUATICUS''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1NG1 is a [ | + | 1NG1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NG1 OCA]. |
==Reference== | ==Reference== | ||
| - | Functional changes in the structure of the SRP GTPase on binding GDP and Mg2+GDP., Freymann DM, Keenan RJ, Stroud RM, Walter P, Nat Struct Biol. 1999 Aug;6(8):793-801. PMID:[http:// | + | Functional changes in the structure of the SRP GTPase on binding GDP and Mg2+GDP., Freymann DM, Keenan RJ, Stroud RM, Walter P, Nat Struct Biol. 1999 Aug;6(8):793-801. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10426959 10426959] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Thermus aquaticus]] | [[Category: Thermus aquaticus]] | ||
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[[Category: srp]] | [[Category: srp]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:56:21 2008'' |
Revision as of 10:56, 20 March 2008
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| , resolution 2.03Å | |||||||
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| Sites: | , , and | ||||||
| Ligands: | , , , and | ||||||
| Gene: | FFH (Thermus aquaticus) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
N AND GTPASE DOMAINS OF THE SIGNAL SEQUENCE RECOGNITION PROTEIN FFH FROM THERMUS AQUATICUS
Overview
Ffh is a component of a bacterial ribonucleoprotein complex homologous to the signal recognition particle (SRP) of eukaryotes. It comprises three domains that mediate both binding to the hydrophobic signal sequence of the nascent polypeptide and the GTP-dependent interaction of Ffh with a structurally homologous GTPase of the SRP receptor. The X-ray structures of the two-domain 'NG' GTPase of Ffh in complex with Mg2+GDP and GDP have been determined at 2.0 A resolution. The structures explain the low nucleotide affinity of Ffh and locate two regions of structural mobility at opposite sides of the nucleotide-binding site. One of these regions includes highly conserved sequence motifs that presumably contribute to the structural trigger signaling the GTP-bound state. The other includes the highly conserved interface between the N and G domains, and supports the hypothesis that the N domain regulates or signals the nucleotide occupancy of the G domain.
About this Structure
1NG1 is a Single protein structure of sequence from Thermus aquaticus. Full crystallographic information is available from OCA.
Reference
Functional changes in the structure of the SRP GTPase on binding GDP and Mg2+GDP., Freymann DM, Keenan RJ, Stroud RM, Walter P, Nat Struct Biol. 1999 Aug;6(8):793-801. PMID:10426959
Page seeded by OCA on Thu Mar 20 12:56:21 2008
Categories: Single protein | Thermus aquaticus | Freymann, D M. | Stroud, R M. | Walter, P. | ACY | CD | EDO | GDP | MG | Ffh | Gdp | Gtpase | Mg | Signal recognition particle | Srp
