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3igq

From Proteopedia

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[[Image:3igq.png|left|200px]]
 
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{{STRUCTURE_3igq| PDB=3igq | SCENE= }}
{{STRUCTURE_3igq| PDB=3igq | SCENE= }}
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===Crystal structure of the extracellular domain of a bacterial pentameric ligand-gated ion channel===
===Crystal structure of the extracellular domain of a bacterial pentameric ligand-gated ion channel===
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{{ABSTRACT_PUBMED_19917292}}
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{{ABSTRACT_PUBMED_19917292}}
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==Function==
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[[http://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>
==About this Structure==
==About this Structure==
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[[3igq]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Gloeobacter_violaceus Gloeobacter violaceus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IGQ OCA].
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[[3igq]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Glovo Glovo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IGQ OCA].
==See Also==
==See Also==
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==Reference==
==Reference==
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<ref group="xtra">PMID:019917292</ref><references group="xtra"/>
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<ref group="xtra">PMID:019917292</ref><references group="xtra"/><references/>
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[[Category: Gloeobacter violaceus]]
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[[Category: Glovo]]
[[Category: Delarue, M.]]
[[Category: Delarue, M.]]
[[Category: Nury, H.]]
[[Category: Nury, H.]]

Revision as of 08:52, 5 February 2014

Template:STRUCTURE 3igq

Contents

Crystal structure of the extracellular domain of a bacterial pentameric ligand-gated ion channel

Template:ABSTRACT PUBMED 19917292

Function

[GLIC_GLOVI] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.[1]

About this Structure

3igq is a 6 chain structure with sequence from Glovo. Full crystallographic information is available from OCA.

See Also

Reference

  • Nury H, Bocquet N, Le Poupon C, Raynal B, Haouz A, Corringer PJ, Delarue M. Crystal structure of the extracellular domain of a bacterial ligand-gated ion channel. J Mol Biol. 2010 Feb 5;395(5):1114-27. Epub 2009 Nov 13. PMID:19917292 doi:10.1016/j.jmb.2009.11.024
  1. ↑ Bocquet N, Prado de Carvalho L, Cartaud J, Neyton J, Le Poupon C, Taly A, Grutter T, Changeux JP, Corringer PJ. A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family. Nature. 2007 Jan 4;445(7123):116-9. Epub 2006 Dec 10. PMID:17167423 doi:10.1038/nature05371

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