3igq
From Proteopedia
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| - | [[Image:3igq.png|left|200px]] | ||
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{{STRUCTURE_3igq| PDB=3igq | SCENE= }} | {{STRUCTURE_3igq| PDB=3igq | SCENE= }} | ||
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===Crystal structure of the extracellular domain of a bacterial pentameric ligand-gated ion channel=== | ===Crystal structure of the extracellular domain of a bacterial pentameric ligand-gated ion channel=== | ||
| + | {{ABSTRACT_PUBMED_19917292}} | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref> | ||
==About this Structure== | ==About this Structure== | ||
| - | [[3igq]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[3igq]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Glovo Glovo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IGQ OCA]. |
==See Also== | ==See Also== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:019917292</ref><references group="xtra"/> | + | <ref group="xtra">PMID:019917292</ref><references group="xtra"/><references/> |
| - | [[Category: | + | [[Category: Glovo]] |
[[Category: Delarue, M.]] | [[Category: Delarue, M.]] | ||
[[Category: Nury, H.]] | [[Category: Nury, H.]] | ||
Revision as of 08:52, 5 February 2014
Contents |
Crystal structure of the extracellular domain of a bacterial pentameric ligand-gated ion channel
Template:ABSTRACT PUBMED 19917292
Function
[GLIC_GLOVI] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.[1]
About this Structure
3igq is a 6 chain structure with sequence from Glovo. Full crystallographic information is available from OCA.
See Also
Reference
- Nury H, Bocquet N, Le Poupon C, Raynal B, Haouz A, Corringer PJ, Delarue M. Crystal structure of the extracellular domain of a bacterial ligand-gated ion channel. J Mol Biol. 2010 Feb 5;395(5):1114-27. Epub 2009 Nov 13. PMID:19917292 doi:10.1016/j.jmb.2009.11.024
- ↑ Bocquet N, Prado de Carvalho L, Cartaud J, Neyton J, Le Poupon C, Taly A, Grutter T, Changeux JP, Corringer PJ. A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family. Nature. 2007 Jan 4;445(7123):116-9. Epub 2006 Dec 10. PMID:17167423 doi:10.1038/nature05371
