2dko

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[[Image:2dko.png|left|200px]]
 
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{{STRUCTURE_2dko| PDB=2dko | SCENE= }}
{{STRUCTURE_2dko| PDB=2dko | SCENE= }}
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===Extended substrate recognition in caspase-3 revealed by high resolution X-ray structure analysis===
===Extended substrate recognition in caspase-3 revealed by high resolution X-ray structure analysis===
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{{ABSTRACT_PUBMED_16787777}}
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{{ABSTRACT_PUBMED_16787777}}
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==Function==
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[[http://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref>
==About this Structure==
==About this Structure==
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[[2dko]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DKO OCA].
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[[2dko]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DKO OCA].
==See Also==
==See Also==
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==Reference==
==Reference==
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<ref group="xtra">PMID:016787777</ref><references group="xtra"/>
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<ref group="xtra">PMID:016787777</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Human]]
[[Category: Ganesan, R.]]
[[Category: Ganesan, R.]]
[[Category: Grutter, M G.]]
[[Category: Grutter, M G.]]

Revision as of 07:17, 2 April 2014

Template:STRUCTURE 2dko

Contents

Extended substrate recognition in caspase-3 revealed by high resolution X-ray structure analysis

Template:ABSTRACT PUBMED 16787777

Function

[CASP3_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.[1] [2]

About this Structure

2dko is a 3 chain structure with sequence from Human. Full crystallographic information is available from OCA.

See Also

Reference

  • Ganesan R, Mittl PR, Jelakovic S, Grutter MG. Extended substrate recognition in caspase-3 revealed by high resolution X-ray structure analysis. J Mol Biol. 2006 Jun 23;359(5):1378-88. Epub 2006 May 11. PMID:16787777 doi:10.1016/j.jmb.2006.04.051
  1. ↑ Nicholson DW, Ali A, Thornberry NA, Vaillancourt JP, Ding CK, Gallant M, Gareau Y, Griffin PR, Labelle M, Lazebnik YA, et al.. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature. 1995 Jul 6;376(6535):37-43. PMID:7596430 doi:http://dx.doi.org/10.1038/376037a0
  2. ↑ Cabrera JR, Bouzas-Rodriguez J, Tauszig-Delamasure S, Mehlen P. RET modulates cell adhesion via its cleavage by caspase in sympathetic neurons. J Biol Chem. 2011 Apr 22;286(16):14628-38. doi: 10.1074/jbc.M110.195461. Epub, 2011 Feb 28. PMID:21357690 doi:10.1074/jbc.M110.195461

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