1nk1
From Proteopedia
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| - | [[Image:1nk1.jpg|left|200px]] | + | [[Image:1nk1.jpg|left|200px]] |
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| - | '''NK1 FRAGMENT OF HUMAN HEPATOCYTE GROWTH FACTOR/SCATTER FACTOR (HGF/SF) AT 2.5 ANGSTROM RESOLUTION''' | + | {{Structure |
| + | |PDB= 1nk1 |SIZE=350|CAPTION= <scene name='initialview01'>1nk1</scene>, resolution 2.50Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= HEPATOCYTE GROWTH FACTOR/SCATTER FACTOR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''NK1 FRAGMENT OF HUMAN HEPATOCYTE GROWTH FACTOR/SCATTER FACTOR (HGF/SF) AT 2.5 ANGSTROM RESOLUTION''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1NK1 is a [ | + | 1NK1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NK1 OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of the NK1 fragment of HGF/SF suggests a novel mode for growth factor dimerization and receptor binding., Chirgadze DY, Hepple JP, Zhou H, Byrd RA, Blundell TL, Gherardi E, Nat Struct Biol. 1999 Jan;6(1):72-9. PMID:[http:// | + | Crystal structure of the NK1 fragment of HGF/SF suggests a novel mode for growth factor dimerization and receptor binding., Chirgadze DY, Hepple JP, Zhou H, Byrd RA, Blundell TL, Gherardi E, Nat Struct Biol. 1999 Jan;6(1):72-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9886295 9886295] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: hgf/sf]] | [[Category: hgf/sf]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:57:52 2008'' |
Revision as of 10:57, 20 March 2008
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| , resolution 2.50Å | |||||||
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| Gene: | HEPATOCYTE GROWTH FACTOR/SCATTER FACTOR (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
NK1 FRAGMENT OF HUMAN HEPATOCYTE GROWTH FACTOR/SCATTER FACTOR (HGF/SF) AT 2.5 ANGSTROM RESOLUTION
Contents |
Overview
Although ligand-induced receptor dimerization is a common prerequisite for receptor activation, the mode by which different growth factors bind their receptors and cause them to dimerize varies considerably. Here we report the crystal structure at 2.5 A resolution of NK1, a receptor-binding fragment and a natural splice variant of hepatocyte growth factor/scatter factor (HGF/SF). NK1 assembles as a homodimer in the asymmetric unit, revealing a novel mode of growth factor dimerization produced by close packing of the N domain of one subunit and the kringle domain of the other, thus bringing the two linkers in close proximity. The structure suggests the presence of a binding site for heparan sulfate chains and a mechanism by which the NK1 dimer may engage two receptor molecules through clusters of amino acids located on each protomer and on opposite surfaces of the homodimer. We also report that short (14-mer) heparin fragments effectively dimerize NK1 in solution, implying that heparan sulfate chains may stabilize the NK1 dimer. These results provide a basis for the agonistic activity of NK1 and have implications for the mechanism of receptor binding of HGF/SF.
Disease
Known diseases associated with this structure: Fibromatosis, gingival OMIM:[182530], Noonan syndrome 4 OMIM:[182530]
About this Structure
1NK1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the NK1 fragment of HGF/SF suggests a novel mode for growth factor dimerization and receptor binding., Chirgadze DY, Hepple JP, Zhou H, Byrd RA, Blundell TL, Gherardi E, Nat Struct Biol. 1999 Jan;6(1):72-9. PMID:9886295
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