1nm7
From Proteopedia
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| - | [[Image:1nm7.gif|left|200px]] | + | [[Image:1nm7.gif|left|200px]] |
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| - | '''Solution structure of the ScPex13p SH3 domain''' | + | {{Structure |
| + | |PDB= 1nm7 |SIZE=350|CAPTION= <scene name='initialview01'>1nm7</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''Solution structure of the ScPex13p SH3 domain''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1NM7 is a [ | + | 1NM7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NM7 OCA]. |
==Reference== | ==Reference== | ||
| - | The ScPex13p SH3 domain exposes two distinct binding sites for Pex5p and Pex14p., Pires JR, Hong X, Brockmann C, Volkmer-Engert R, Schneider-Mergener J, Oschkinat H, Erdmann R, J Mol Biol. 2003 Mar 7;326(5):1427-35. PMID:[http:// | + | The ScPex13p SH3 domain exposes two distinct binding sites for Pex5p and Pex14p., Pires JR, Hong X, Brockmann C, Volkmer-Engert R, Schneider-Mergener J, Oschkinat H, Erdmann R, J Mol Biol. 2003 Mar 7;326(5):1427-35. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12595255 12595255] |
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: yeast]] | [[Category: yeast]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:58:41 2008'' |
Revision as of 10:58, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution structure of the ScPex13p SH3 domain
Overview
Pex13p is an essential component of the peroxisomal protein import machinery and interacts via its C-terminal SH3 domain with the type II SH3-ligand Pex14p and the non-PXXP protein Pex5p. We report the solution structure of the SH3 domain of Pex13p from Saccharomyces cerevisiae and the identification of a novel-binding pocket, which binds a non-PXXP-peptide representing the binding site of Pex5p. Chemical shift assays revealed the binding sites for Pex5p and Pex14p ligand peptides to be distinct and spatially separated. Competition assays demonstrated that the two ligand peptides can bind simultaneously to the SH3 domain.
About this Structure
1NM7 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
The ScPex13p SH3 domain exposes two distinct binding sites for Pex5p and Pex14p., Pires JR, Hong X, Brockmann C, Volkmer-Engert R, Schneider-Mergener J, Oschkinat H, Erdmann R, J Mol Biol. 2003 Mar 7;326(5):1427-35. PMID:12595255
Page seeded by OCA on Thu Mar 20 12:58:41 2008
