3d80
From Proteopedia
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{{STRUCTURE_3d80| PDB=3d80 | SCENE= }} | {{STRUCTURE_3d80| PDB=3d80 | SCENE= }} | ||
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===Structural Analysis of a Holo Enzyme Complex of Mouse Dihydrofolate Reductase with NADPH and a Ternary Complex wtih the Potent and Selective Inhibitor 2,4-Diamino-6-(2'-hydroxydibenz[b,f]azepin-5-yl)methylpteridine=== | ===Structural Analysis of a Holo Enzyme Complex of Mouse Dihydrofolate Reductase with NADPH and a Ternary Complex wtih the Potent and Selective Inhibitor 2,4-Diamino-6-(2'-hydroxydibenz[b,f]azepin-5-yl)methylpteridine=== | ||
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{{ABSTRACT_PUBMED_18703847}} | {{ABSTRACT_PUBMED_18703847}} | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/DYR_MOUSE DYR_MOUSE]] Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1. | ||
==About this Structure== | ==About this Structure== | ||
[[3d80]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D80 OCA]. | [[3d80]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D80 OCA]. | ||
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| - | ==See Also== | ||
| - | *[[Dihydrofolate reductase|Dihydrofolate reductase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:018703847</ref><references group="xtra"/> | + | <ref group="xtra">PMID:018703847</ref><references group="xtra"/><references/> |
[[Category: Dihydrofolate reductase]] | [[Category: Dihydrofolate reductase]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
Revision as of 21:07, 19 June 2013
Contents |
Structural Analysis of a Holo Enzyme Complex of Mouse Dihydrofolate Reductase with NADPH and a Ternary Complex wtih the Potent and Selective Inhibitor 2,4-Diamino-6-(2'-hydroxydibenz[b,f]azepin-5-yl)methylpteridine
Template:ABSTRACT PUBMED 18703847
Function
[DYR_MOUSE] Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.
About this Structure
3d80 is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
- Cody V, Pace J, Rosowsky A. Structural analysis of a holoenzyme complex of mouse dihydrofolate reductase with NADPH and a ternary complex with the potent and selective inhibitor 2,4-diamino-6-(2'-hydroxydibenz[b,f]azepin-5-yl)methylpteridine. Acta Crystallogr D Biol Crystallogr. 2008 Sep;64(Pt 9):977-84. Epub 2008, Aug 13. PMID:18703847 doi:10.1107/S0907444908022348
