1gwp
From Proteopedia
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| - | [[Image:1gwp.png|left|200px]] | ||
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{{STRUCTURE_1gwp| PDB=1gwp | SCENE= }} | {{STRUCTURE_1gwp| PDB=1gwp | SCENE= }} | ||
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===STRUCTURE OF THE N-TERMINAL DOMAIN OF THE MATURE HIV-1 CAPSID PROTEIN=== | ===STRUCTURE OF THE N-TERMINAL DOMAIN OF THE MATURE HIV-1 CAPSID PROTEIN=== | ||
| + | {{ABSTRACT_PUBMED_12032547}} | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/GAG_HV1N5 GAG_HV1N5]] Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu. Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity). | ||
==About this Structure== | ==About this Structure== | ||
| - | [[1gwp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[1gwp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hiv-1 Hiv-1]. This structure supersedes the now removed PDB entries and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1gdz 1gdz]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GWP OCA]. |
==See Also== | ==See Also== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:012032547</ref><references group="xtra"/> | + | <ref group="xtra">PMID:012032547</ref><references group="xtra"/><references/> |
| + | [[Category: Hiv-1]] | ||
[[Category: Gitti, R K.]] | [[Category: Gitti, R K.]] | ||
[[Category: Lee, B M.]] | [[Category: Lee, B M.]] | ||
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[[Category: Hiv-1 ca-151]] | [[Category: Hiv-1 ca-151]] | ||
[[Category: Human immunodeficiency virus type 1 capsid protein]] | [[Category: Human immunodeficiency virus type 1 capsid protein]] | ||
| + | [[Category: Viral protein]] | ||
[[Category: Virus capsid protein]] | [[Category: Virus capsid protein]] | ||
[[Category: Virus maturation]] | [[Category: Virus maturation]] | ||
Revision as of 09:01, 5 February 2014
Contents |
STRUCTURE OF THE N-TERMINAL DOMAIN OF THE MATURE HIV-1 CAPSID PROTEIN
Template:ABSTRACT PUBMED 12032547
Function
[GAG_HV1N5] Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu. Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity).
About this Structure
1gwp is a 1 chain structure with sequence from Hiv-1. This structure supersedes the now removed PDB entries and 1gdz. Full experimental information is available from OCA.
See Also
Reference
- Tang C, Ndassa Y, Summers MF. Structure of the N-terminal 283-residue fragment of the immature HIV-1 Gag polyprotein. Nat Struct Biol. 2002 Jul;9(7):537-43. PMID:12032547 doi:10.1038/nsb806
