2v26

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[[Image:2v26.png|left|200px]]
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==MYOSIN VI (MD) PRE-POWERSTROKE STATE (MG.ADP.VO4)==
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<StructureSection load='2v26' size='340' side='right' caption='[[2v26]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2v26]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V26 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V26 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2bkh|2bkh]], [[2bki|2bki]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v26 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v26 RCSB], [http://www.ebi.ac.uk/pdbsum/2v26 PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v2/2v26_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Due to a unique addition to the lever arm-positioning region (converter), class VI myosins move in the opposite direction (toward the minus-end of actin filaments) compared to other characterized myosin classes. However, the large size of the myosin VI lever arm swing (powerstroke) cannot be explained by our current view of the structural transitions that occur within the myosin motor. We have solved the crystal structure of a fragment of the myosin VI motor in the structural state that represents the starting point for movement on actin; the pre-powerstroke state. Unexpectedly, the converter itself rearranges to achieve a conformation that has not been seen for other myosins. This results in a much larger powerstroke than is achievable without the converter rearrangement. Moreover, it provides a new mechanism that could be exploited to increase the powerstroke of yet to be characterized plus-end-directed myosin classes.
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{{STRUCTURE_2v26| PDB=2v26 | SCENE= }}
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The structural basis for the large powerstroke of myosin VI.,Menetrey J, Llinas P, Mukherjea M, Sweeney HL, Houdusse A Cell. 2007 Oct 19;131(2):300-8. PMID:17956731<ref>PMID:17956731</ref>
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===MYOSIN VI (MD) PRE-POWERSTROKE STATE (MG.ADP.VO4)===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_17956731}}
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==About this Structure==
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[[2v26]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V26 OCA].
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==See Also==
==See Also==
*[[Myosin|Myosin]]
*[[Myosin|Myosin]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:017956731</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
[[Category: Houdusse, A.]]
[[Category: Houdusse, A.]]

Revision as of 09:02, 29 September 2014

MYOSIN VI (MD) PRE-POWERSTROKE STATE (MG.ADP.VO4)

2v26, resolution 1.75Å

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