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3nr6

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[[Image:3nr6.png|left|200px]]
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==Crystal structure of xenotropic murine leukemia virus-related virus (XMRV) protease==
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<StructureSection load='3nr6' size='340' side='right' caption='[[3nr6]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3nr6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NR6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NR6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2hvp|2hvp]], [[4fiv|4fiv]], [[2fmb|2fmb]], [[2i1a|2i1a]], [[2rsp|2rsp]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gag-pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10239 Viruses])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nr6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nr6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nr6 RCSB], [http://www.ebi.ac.uk/pdbsum/3nr6 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Using energy and density guided Rosetta refinement to improve molecular replacement, we determined the crystal structure of the protease encoded by xenotropic murine leukemia virus-related virus (XMRV). Despite overall similarity of XMRV protease to other retropepsins, the topology of its dimer interface more closely resembles those of the monomeric, pepsin-like enzymes. Thus, XMRV protease may represent a distinct branch of the aspartic protease family.
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{{STRUCTURE_3nr6| PDB=3nr6 | SCENE= }}
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Crystal structure of XMRV protease differs from the structures of other retropepsins.,Li M, Dimaio F, Zhou D, Gustchina A, Lubkowski J, Dauter Z, Baker D, Wlodawer A Nat Struct Mol Biol. 2011 Jan 23. PMID:21258323<ref>PMID:21258323</ref>
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===Crystal structure of xenotropic murine leukemia virus-related virus (XMRV) protease===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_21258323}}
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==About this Structure==
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[[3nr6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NR6 OCA].
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==See Also==
==See Also==
*[[Virus protease|Virus protease]]
*[[Virus protease|Virus protease]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021258323</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Viruses]]
[[Category: Viruses]]
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[[Category: Dauter, Z.]]
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[[Category: Dauter, Z]]
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[[Category: Gustchina, A.]]
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[[Category: Gustchina, A]]
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[[Category: Li, M.]]
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[[Category: Li, M]]
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[[Category: Lubkowski, J.]]
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[[Category: Lubkowski, J]]
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[[Category: Wlodawer, A.]]
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[[Category: Wlodawer, A]]
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[[Category: Zhou, D.]]
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[[Category: Zhou, D]]
[[Category: Dimer]]
[[Category: Dimer]]
[[Category: Hydrolase-inhibitor complex]]
[[Category: Hydrolase-inhibitor complex]]
[[Category: Protease]]
[[Category: Protease]]

Revision as of 13:25, 9 December 2014

Crystal structure of xenotropic murine leukemia virus-related virus (XMRV) protease

3nr6, resolution 1.97Å

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